Assessing renal graft function in clinical trials: Can tests predicting glomerular filtration rate substitute for a reference method?

Mariat, Christophe; Alamartine, Éric; Barthélémy, Jean‐Claude; Filippis, Jean-Pierre De; Thibaudin, Damien; Berthoux, P; Laurent, B.; Thibaudin, Lise; Berthoux, F

doi:10.1111/j.1523-1755.2004.00350.x

Cited by 116 publications

(106 citation statements)

References 22 publications

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“…This is partly explained by the fact that equations based on creatinine considerably overestimate GFR in renal transplantation (154)(155)(156). Overall, equations using CysC appear to offer better predictive performance, although it remains to be shown that this improvement in prediction is clinically significant (52, 131, 133, 157, 158).…”

Section: Utility Of Cysc In Transplantationmentioning

confidence: 89%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

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163

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Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86.

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Section: Utility Of Cysc In Transplantationmentioning

confidence: 89%

Cystatin C: current position and future prospects

Séronie-Vivien

Delanaye

Piéroni³

et al. 2008

Clinical Chemistry and Laboratory Medicine

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163

145

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“…This formula compares favorably with others in terms of dispersion when compared with inulin clearance in the renal transplant population (17). Proteinuria was measured from a 24-h urine collection.…”

Section: Determinationsmentioning

confidence: 99%

Unmasking Glucose Metabolism Alterations in Stable Renal Transplant Recipients

Delgado¹,

Dı́az²,

Silva³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: Emerging information indicates that glucose metabolism alterations are common after renal transplantation and are associated with carotid atheromatosis. The aims of this study were to investigate the prevalence of different glucose metabolism alterations in stable recipients as well as the factors related to the condition.Design, setting, participants, & measurements: A multicenter, cross-sectional study was conducted of 374 renal transplant recipients without pre-or posttransplantation diabetes. A standard 75-g oral glucose tolerance test was performed.Results: Glucose metabolism alterations were present in 119 (31.8%) recipients: 92 (24.6%) with an abnormal oral glucose tolerance test and 27 (7.2%) with isolated impaired fasting glucose. The most common disorder was impaired glucose tolerance (17.9%), and an abnormal oral glucose tolerance test was observed for 21.5% of recipients with a normal fasting glucose. By multivariate analysis, age, prednisone dosage, triglyceride/high-density lipoprotein cholesterol ratio, and ␤ blocker use were shown to be factors related to glucose metabolism alterations. Remarkably, triglyceride levels, triglyceride/high-density lipoprotein cholesterol ratio, and the proportion of recipients with impaired fasting glucose were already higher throughout the first posttransplantation year in recipients with a current glucose metabolism alteration as compared with those without the condition.Conclusions: Glucose metabolism alterations are common in stable renal transplant recipients, and an oral glucose tolerance test is required for its detection. They are associated with a worse metabolic profile, which is already present during the first posttransplantation year. These findings may help planning strategies for early detection and intervention.

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“…The Modification of Diet in Renal Disease method was used to estimate creatinine clearance because it has been shown that values that are derived by this formula correlate better than other available equations with true GFR in transplant recipients (10,11). Biopsy-confirmed acute rejection (BCAR) and chronic allograft nephropathy (CAN) were defined according to Banff 93 and 97 criteria, respectively (12,13).…”

Section: Variables and Definitions Of Variablesmentioning

confidence: 99%