Assessing Predictive Ability of Biomarkers for Pediatric Acute Kidney Injury: Methodological Issues

Reply

“…As Xue and colleagues noted [1], we included the area under the receiver operating characteristic curve (AUC-ROC) in our report [2]. The AUC-ROC index has an interpretation as a concordance measure: for a randomly selected patient experiencing the event (a "case") and a randomly selected patient not experiencing the event (a "control"), AUC-ROC equals the probability the case patient has a higher biomarker value than the control patient.…”

“…The direction of travel in the study of pulmonary autograft (PA) durability is based on the biomechanical evaluations of root and leaflets, as testified by several reports published in The Annals [1,2]. In our work on biomechanical modeling of the Ross operation [3], we have often cited the study by Horer and colleagues [4] that appeared in The Annals as reference values for the yearly expansion of the different segments of the PA.…”