Assessing PDL-1 and PD-1 in Non–Small Cell Lung Cancer: A Novel Immunoscore Approach

Abstract

Our study identified S-PD-L1 and T-PD-1 as independent positive prognostic factors for NSCLC patients. Their combination added significant prognostic impact within each pathologic stage and hence are feasible to include in a TNM Immunoscore.

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

“…Conversely, low PD-L1-positive immune-cell density in the stromal compartment and low PD-1-positive intraepithelial TILs were associated with poor disease-specific survival across all disease stages (HR = 1.81; 95% CI 1.37–2.40; P <0.001). The contribution of both factors was shown to be significant in multivariate analyses, indicating that they are independent prognostic factors 65 . The utility of the immunoscore to predict tumour response to therapy of patients with advanced-stage NSCLC remains to be further investigated.…”

“…The immunoscore remains to be prospectively evaluated in patients with NSCLC; however, in one study, tumour tissue samples from 536 patients with stage I–IIIA NSCLC were evaluated, revealing that a high density of PD-L1-positive immune cells in the stromal compartment, and of PD-1-positive intraepithelial TILs was associated with favourable disease-specific survival 65 . Conversely, low PD-L1-positive immune-cell density in the stromal compartment and low PD-1-positive intraepithelial TILs were associated with poor disease-specific survival across all disease stages (HR = 1.81; 95% CI 1.37–2.40; P <0.001).…”

Local immune parameters as potential predictive markers in head and neck squamous cell carcinoma patients receiving induction chemotherapy and cetuximab

“…Our finding of increased amount of PD‐1 + lymphocytes in tumors of responding patients is interesting because, although PD‐1 is classified as a marker of T‐cell exhaustion, it has also been proved an activation marker expressed predominantly by tumor‐reactive infiltrating T cells . There are conflicting results on the prognostic effect of PD‐1 expression by tumor‐infiltrating immune cells, with negative effect in the case of renal and breast carcinomas while positive one in others, as ovarian, pancreatic, colorectal, and lung cancer . High level of PD‐1 expression was detected in HNSCC TILs, and their amount proved a favorable prognostic marker .…”

The importance of programmed death ligand 1 gene expression, epidermal growth factor receptor gene mutations and serum epidermal growth factor receptor levels in Turkish non-small cell lung cancer patients

“…Survival of patients according to serum epidermal growth factor receptor levels. Paulsen et al [15] performed a histopathological examination of PD-1 and PD-L1 in NSCLC and emphasized their prognostic significance. They also emphasized that co-evaluation of PD-1 and PD-L1 was critical for an accurate TNM staging and prognosis.…”