SummaryObjectives: To examine the relationships between dental appearance, characteristics of the individual and their environment and OHQoL in young people over time.Methods: 374 young people (122 boys, 252 girls) aged 11-12 years from 7 different UK schools were recruited at baseline and 258 (78 boys, 180 girls) followed-up 3 years later, aged 14-15 years (69% response rate). Participants completed a measure of OHQoL (CPQ11-14 ISF-16) and self-esteem (SE, CHQ-CF87). A clinical examination was undertaken, including clinician and self-assessed normative measures of need (IOTN) and dental caries. The Index of Multiple Deprivation was used to indicate socio-economic status (SES).Results: There was a general improvement between baseline and follow-up in the measures of malocclusion, as well as OHQoL. Multiple linear regression indicated that there were significant cross-sectional associations at baseline between OHQoL and SES (rho = -0.11; P=0.006), SE (rho = -0.50; P<0.001) and self-assessed IOTN (rho = 0.27; P<0.001). There were significant longitudinal associations between the change in OHQoL and change in SE (rho = -0.46; P<0.001) and change in the DMFS (rho = -0.24; P=0.001). The mean improvement in the total CPQ11-14 ISF-16 score for those with a history of orthodontic treatment was 3.2 (SD 6.9; P=0.009) and 2.4 (SD 8.8; P<0.001) for those with no history of treatment. The difference was not statistically significant (P=0.584).Conclusions: OHQoL improved in young people over time, whether they gave a history of orthodontic treatment or not. Individual and environmental characteristics influence OHQoL and should be taken into account in future studies.