Assessing nest-building behavior of mice using a 3D depth camera

Okayama, Takayuki; Goto, Tatsuhiko; Toyoda, Atsushi

doi:10.1016/j.jneumeth.2015.05.019

Cited by 14 publications

(18 citation statements)

References 26 publications

(30 reference statements)

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“…Although it was not investigated in the current study, changes in nest building can provide a general view of a mouse’s anxiety state, and is an indication of psychological distress 68 in gestationally stressed dams. Thus, assessing nest structure and quality in a systematic manner 69, 70 in future studies would be a useful way to test anxiety-like behaviour in stressed mice during peripartum and the early postpartum days.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, even in the absence of hormonal indicator of the stress response, we believe that the alterations found in the present study demonstrates a difference in the effects of the two stressors. In addition, investigating the health condition of the AS pups who did not survive after birth, as well as exploring maternal behaviour of the dams during the late peripartum and the early postpartum periods 68, 70 can help to make clear the influence of pups health as well as maternal anxiety on loss of pups in the early PD. Finally, pre-exposure to an elevated platform as a stressor for the PS group could influence the later behaviour of the PS dams in both EPM and BBT.…”

Section: Discussionmentioning

confidence: 99%

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The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

Jafari

Faraji

Agha

et al. 2017

Sci Rep

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Stress during gestation has harmful effects on pregnancy outcome and can lead to spontaneous abortion. Few studies, however, have addressed the impact of gestational stress, particularly auditory stress, on behavioural performance and pregnancy outcome in mice. This study aimed to examine the effect of two types of gestational stress on uterus receptivity and behavioural performance. Pregnant C57BL/6 mice were randomly assigned to either auditory or physical stress conditions or a control condition from gestational days 12–16. The auditory stress regimen used loud 3000 Hz tone, while the physical stressor consisted of restraint and exposure to an elevated platform. Three behavioural tests were performed in the dams after weaning. Uterine receptivity was investigated by counting the number of sites of implantation and fetal resorption. Also, the offspring survival rates during the early postnatal period were calculated. Auditory stress caused an increase in anxiety-like behaviour, reduced time spent exploring new object/environment, and reduced balance when compared to the physical stress and control groups. Auditory stress also caused higher rates of resorbed embryos and reduction of litter size. Our results suggest that the adverse effect of noise stress is stronger than physical stress for both uterus receptivity and behavioural performance of the dams.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

Jafari

Faraji

Agha

et al. 2017

Sci Rep

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“…Matsumoto et al constructed skeleton models of rats using four 3D cameras simultaneously and analyzed social and sexual interactions and novel object recognition behavior (Matsumoto et al, 2013 , 2014 ). We monitored nest-building behavior in mice using a 3D camera (Okayama et al, 2015 ), and confirmed its effective utilization in a genetic study (Goto et al, 2015b ). Nakamura et al have developed a gait analysis system for mice using a 3D camera (Nakamura et al, 2015 ).…”

Section: A Novel 3d Behavioral Testing Methods For Innate Behavior (Fimentioning

confidence: 53%

Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects

et al. 2016

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Advanced societies face increased health problems related to various stresses. Chronic psychological stress is a major risk factor for psychiatric disorders such as depression. Although therapeutic agents reduce several symptoms of depression, most have side effects in a broad range of the population. Furthermore, some victims of depression do not show significant improvement with any drugs, so alternative approaches are needed. Good dietary habits may potentially reduce depressive symptoms, but there is little scientific evidence thus far. Murine depression models are useful to test nutritional approaches in vivo. Our model mice subjected to a subchronic mild social defeat stress (sCSDS) paradigm show several alterations in physiological parameters and social behavior. These stress-induced symptoms in sCSDS mice can be used as cues to identify antidepressant-like natural resources including foods and farm products. We previously discovered that sCSDS mice show more vulnerability to social stress by changing dietary condition. In addition, we developed a more objective system for analyzing mouse behavior using a 3D depth-sensing camera to understand relationships between diet and behavior. The combination of sCSDS mice with 3D behavioral analysis is a powerful method for screening ingredients in foods and farm products for antidepressant-like effects.

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“…Furthermore, in the future, automatic analysis systems for the evaluation of nest quality should be developed for efficient screening (Okayama et al . ; Goto et al . ).…”

Section: Perspectives For the Application Of Rodent Models To Animal mentioning

confidence: 99%

“…Therefore, a paradigm that consists of acute social defeat stress and an evaluation of nest quality will be a convenient tool for screening functional foods and reagents that could potentially contribute to the prevention and treatment of depression. Furthermore, in the future, automatic analysis systems for the evaluation of nest quality should be developed for efficient screening (Okayama et al 2015;Goto et al 2016b).…”

Section: Discovery Of Foods and Nutrients For The Prevention Of Deprementioning

confidence: 99%

Social defeat models in animal science: What we have learned from rodent models

Toyoda

2017

Animal Science Journal

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Studies on stress and its impacts on animals are very important in many fields of science, including animal science, because various stresses influence animal production and animal welfare. In particular, the social stresses within animal groups have profound impact on animals, with the potential to induce abnormal behaviors and health problems. In humans, social stress induces several health problems, including psychiatric disorders. In animal stress models, social defeat models are well characterized and used in various research fields, particularly in studies concerning mental disorders. Recently, we have focused on behavior, nutrition and metabolism in rodent models of social defeat to elucidate how social stresses affect animals. In this review, recent significant progress in studies related to animal social defeat models are described. In the field of animal science, these stress models may contribute to advances in the development of functional foods and in the management of animal welfare.

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Assessing nest-building behavior of mice using a 3D depth camera

Cited by 14 publications

References 26 publications

The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

Murine Depression Model and its Potential Applications for Discovering Foods and Farm Products with Antidepressant-Like Effects

Social defeat models in animal science: What we have learned from rodent models

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