Assessing nanoparticle colloidal stability with single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS)

Donahue, Nathan; Francek, Emmy R.; Kiyotake, Emi A.; Thomas, Emily E.; Yang, Wen; Wang, Lin; Detamore, Michael S.; Wilhelm, Stefan

doi:10.1007/s00216-020-02783-6

Cited by 25 publications

(29 citation statements)

References 52 publications

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“…Many methods have been employed for studying the pathways that nanoparticles take, both with and without active targeting. The use of small molecule inhibitors has been a popular method for blocking an endocytic pathway and observing changes in cellular uptake, through methods such as fluorescence microscopy, [ 148 ] flow cytometry, [ 149 ] inductively coupled plasma mass spectrometry, [ 150–152 ] and radioactive decay measurements. [ 153 ] A common control for these studies is cooling the cells being studied to 4 °C, as this nonspecifically inhibits all endocytosis.…”

Section: Tools and Techniques To Investigate Nanoparticle Transport Pmentioning

confidence: 99%

Strategies for Delivering Nanoparticles across Tumor Blood Vessels

Sheth

Wang

Bhattacharya

et al. 2020

Adv Funct Materials

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Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery process are not fully understood. Here, the biological and physical characteristics of the tumor vasculature and the tumor microenvironment are explored and how these features affect nanoparticle transport across tumor blood vessels is discussed. The biological and physical methods to deliver nanoparticles into tumors are reviewed and paracellular and transcellular nanoparticle transport pathways are explored. Understanding the underlying pathways and mechanisms of nanoparticle tumor delivery will inform the engineering of safer and more effective nanomedicines for clinical translation.

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Section: Tools and Techniques To Investigate Nanoparticle Transport Pmentioning

confidence: 99%

Strategies for Delivering Nanoparticles across Tumor Blood Vessels

Sheth

Wang

Bhattacharya

et al. 2020

Adv Funct Materials

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“…28 Such techniques can quantify the iron-positive cells in an organ, measure the iron loading in one cell, isolate the signal from the particles against the background of iron ions, or even assess the aggregation state of particles. 29 Counting and sizing of the nanoparticles with ICP-MS 30 can discover processes of iron oxide dissolution and transport in the organism. Nevertheless, mass spectrometry cannot give information about changes in the crystal structure of nanoparticles and show process of biotransformation of iron oxides from nonlinear magnets into biogenic iron forms.…”

mentioning

confidence: 99%

“…However, some modern mass spectrometry approaches can effectively analyze individual cells or even nanoparticles . Such techniques can quantify the iron-positive cells in an organ, measure the iron loading in one cell, isolate the signal from the particles against the background of iron ions, or even assess the aggregation state of particles . Counting and sizing of the nanoparticles with ICP-MS can discover processes of iron oxide dissolution and transport in the organism.…”

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confidence: 99%

Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study

et al. 2021

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Safe application of nanoparticles in medicine requires full understanding of their pharmacokinetics including catabolism in the organism. However, information about nanoparticle degradation is still scanty due to difficulty of long-term measurements by invasive techniques. Here, we describe a magnetic spectral approach for in vivo monitoring of magnetic particle (MP) degradation. The method noninvasiveness has allowed performing of a broad comprehensive study of the 1-year fate of 17 types of iron oxide particles. We show a long-lasting influence of five parameters on the MP degradation half-life: dose, hydrodynamic size, ζ-potential, surface coating, and internal architecture. We observed a slowdown in MP biotransformation with an increase of the injected dose and faster degradation of the particles of a small hydrodynamic size. A comparison of six types of 100 nm particles coated by different hydrophilic polymer shells has shown that the slowest (t 1/2 = 38 ± 6 days) and the fastest (t 1/2 = 15 ± 4 days) degradations were achieved with a polyethylene glycol and polyglucuronic acid coatings, respectively. The most significant influence on the MP degradation was due to the internal architecture of the particles as the coverage of magnetic cores with a solid 39 nm polystyrene layer slowed down the half-life of the core−shell MPs from 48 days to more than 1 year. The revealed deeper insights into the particle degradation in vivo may facilitate rational design of nano-and microparticles with predictable long-term fate in vivo.

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“…Table 1 summarises the quantitative and characterisation information with the corresponding measurands for each of the analytes involved in SP-ICP-MS. Qualitative information about the presence/absence of dissolved species and/or nanoparticles over a certain concentration and size cannot be disregarded because of the practical limitations of the technique when analysing complex samples, as it will be shown below. In addition, other types of information can be obtained from SP-ICP-MS measurements (e.g., porosity, 22 density, 23 aggregation, 24,25 agglomeration 26 ), although they will not be discussed in detail.…”

Section: Analytical Information: Analytes and Measurandsmentioning

confidence: 99%