Assessing iron status of a population

Cook, JD; Finch, Clement A.

doi:10.1093/ajcn/32.10.2115

Cited by 261 publications

(191 citation statements)

References 12 publications

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“…This is most probably due to the use of different standards (9). The separation between patients and healthy control subjects was better for the iron-overload patients than for the iron-deficient anemia patients, which is in harmony with the prevalence of these disorders in the population (19)(20)(21). In contrast to men and postmenopausal women, serum ferritin concentrations in younger women were found to be close to those in iron-deficient anemia patients.…”

Section: Discussionmentioning

confidence: 66%

Measurement of ferritin in serum: Application in Diagnostic use

Oost¹,

Beld²,

Cloin³

et al. 1984

Clinical Biochemistry

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A sandwich-type radioimmunoassay for serum ferritin was developed using iron-rich human liver ferritin and evaluated for its clinical usefulness. In young healthy males and females, the mean serum ferritin concentrations were 44 ~g/L (range 7-158) and 16 p.g/L (range 4-56), respectively. In anemic patients lower serum ferritin concentrations were found, while in most patients with iron overload serum ferritin concentrations well above 1000 ~g/L were measured. Comparison of our method with a commercially available radioimmunoassay kit revealed a good correlation, except for sera with very low ferritin concentrations. Comparison with serum iron and transferrin parameters in patients with iron deficiency demonstrated that serum ferritin concentrations might be subnormal in a majority of patients with otherwise normal iron indices. Up to 70% of the ferritin in serum of normal subjects could bind to concanavalin A-Sepharose, indicating its glycoprotein nature. It is concluded that our serum ferritin radioimmunoassay gave reliable results and was useful in the laboratory diagnosis of latent iron-deficiency and in the analysis of the heterogeneity of serum ferritin.

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Section: Discussionmentioning

confidence: 66%

Measurement of ferritin in serum: Application in Diagnostic use

Oost¹,

Beld²,

Cloin³

et al. 1984

Clinical Biochemistry

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“…In such contexts, no single measurement when used alone may be considered specific enough to identify ID (5,6,32) . As suggested in other studies (33,34) , in the current research ID was defined by at least two abnormal values among the three parameters of Fe status used. According to this multiple criteria model, we found that almost 32 % of the adolescent girls were Fe-deficient which is similar to the prevalence seen among menstruating women from Côte d'Ivoire (35 %) (20) .…”

Section: Discussionmentioning

confidence: 92%

Iron status of adolescent girls from two boarding schools in southern Benin

Alaofè

Zee

Dossa

et al. 2008

Public Health Nutr.

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Iron deficiency (ID) is the most prevalent micronutrient deficiency in the world, particularly in developing countries. Blood samples and a qualitative FFQ on Feand vitamin C-rich foods were obtained in 180 adolescent girls aged 12 to 17 years living in two boarding schools from south Benin. ID, defined as serum ferritin either ,20 mg/l or 20-50 mg/l, plus two of the following parameters: serum Fe , 11 mmol/l, total iron-binding capacity . 73 mmol/l or transferrin saturation , 20 %, was found in 32 % of subjects. Anaemia (Hb , 120 g/l) was found in 51 % of adolescents, while 24 % suffered from iron-deficiency anaemia (IDA) (ID and Hb , 20 g/l). After adjusting for confounding factors (age, mother's and father's occupation, household size) in a logistic regression equation, subjects having a low meat consumption (beef, mutton, pork) (,4 times/week) were more than twice as likely to suffer from ID (OR 5 2?43; 95 % CI 1?72, 3?35; P 5 0?04). Adolescents consuming less fruits (,4 times/week) also had a higher likelihood of suffering from ID (OR 5 1?53; 95 % CI 1?31, 2?80; P 5 0?03). Finally, subjects whose meat consumption was low were twice as likely to suffer from IDA (OR 5 2?24; 95 % CI 1?01, 4?96; P 5 0?04). The prevalence of ID represents an important health problem in these Beninese adolescent girls. A higher consumption of Fe-rich foods and of promoters of Fe absorption (meat factor and vitamin C) is recommended to prevent ID deficiency in these subjects.

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“…As no single indicator reflects the entire spectrum of iron status (Cook et al, 1976), we used a common multiple biochemical test strategy (Yip et al, 1984;Expert Scientific Working Group, 1985;English & Bennett, 1990;Preziosi et al, 1994). Our model included SF, TfS and Hb.…”

Section: Venous Blood Samplesmentioning

confidence: 99%