Assessing immuno-expression of p53 protein and TP 53 gene amplification in histologically negative surgical margins of oral squamous cell carcinoma patients and normal oral mucosa

Kamat, Mamata; Puranik, Rudrayya S; Das, A Bhagavan; Patil, B. R.; Patil, Shankargouda

doi:10.1007/s00784-022-04574-y

Cited by 1 publication

(1 citation statement)

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“…Dysregulation of TP53 may affect the senescence program in oral squamous cells, in uencing the aging process and cellular turnover within the epithelium. Understanding these potential interactions between TP53 mutations and the developmental biology elements in oral squamous epithelium provides insights into the processes that may contribute to the initiation and progression of oral squamous cell carcinoma [25].…”

Section: Tp53 Mutations In Relation To Developmental Dynamics Of Oral...mentioning

confidence: 99%

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

Shafi,

Aakash,

Haseeb

et al. 2024

Preprint

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Background: Oral Squamous Cell Carcinoma (OSCC) poses a global health challenge, demanding an in-depth understanding of its mutational landscape. The complex mutational profile underscores the need for targeted therapies. OSCC's impact on crucial functions necessitates precise interventions for improved patient outcomes. This investigation into OSCC's mutational landscape through developmental biology aims to fill critical knowledge gaps, contributing possibly towards future personalized therapies and advancing our approach to this challenging malignancy. Methods: Databases, including PubMed, MEDLINE, Google Scholar, and open access/subscription-based journals were searched for published articles without any date restrictions, to investigate the mutational landscape of OSCC through the lens of developmental dynamics. Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate OSCC oncogenesis. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Results: This study into Oral Squamous Cell Carcinoma (OSCC) reveals a complex genetic landscape marked by mutations in key regulators including TP53, CASP8, CDKN2A, FAT1, PIK3CA, and RYR2. TP53 emerges as a central player, with mutations disrupting its tumor-suppressive functions and influencing developmental processes in OSCC. Dysregulated Notch1 signaling contributes to aberrant cell differentiation and tissue morphogenesis. JAK/STAT and SHH signaling, essential for normal oral epithelial development, exhibit dual dynamics in OSCC, influencing both normal developmental processes and tumorigenesis. Implications for precision medicine arise from the identified genetic alterations, offering potential targets for future therapeutic interventions. Notch1 and TP53 signaling pathways emerge as promising targets, while modulating JAK/STAT and SHH signaling presents challenges and opportunities for new therapeutic strategies. Conclusion: This study reveals genetic complexities and regulatory networks disrupted in OSCC carcinogenesis and also playing key roles in developmental dynamics of oral squamous epithelium. Key genes like TP53 and Notch1, integral to oral epithelial development, undergo dysregulation, influencing OSCC initiation. JAK/STAT and SHH signaling, crucial in normal development, exhibit dual roles, contributing to OSCC progression. This study also points to targeted therapeutic strategies that may emerge in future by investigating OSCC through developmental dynamics. Further research may provide deeper insights into the complex developmental biology, paving the way for enhanced interventions in OSCC.

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Section: Tp53 Mutations In Relation To Developmental Dynamics Of Oral...mentioning

confidence: 99%

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

Shafi,

Aakash,

Haseeb

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Assessing immuno-expression of p53 protein and TP 53 gene amplification in histologically negative surgical margins of oral squamous cell carcinoma patients and normal oral mucosa

Cited by 1 publication

References 24 publications

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

Mutational Landscape of Oral Squamous Cell Carcinoma Investigated Through the Developmental Dynamics of Oral Squamous Epithelium

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