Assessing human exposure risk to cadmium through inhalation and seafood consumption

Ju, Yun-Ru; Chen, Wei Yu; Liao, Chung‐Min

doi:10.1016/j.jhazmat.2012.05.060

Cited by 42 publications

(24 citation statements)

References 57 publications

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“…Although air pollution from traffic exhausts was identified as a possible source of Cd (21), contribution from diets cannot be ruled out. Dietary intake is one of the important sources of exposure to Cd in the general nonsmoking population, especially in consumption of some foods such as rice, other crops, and shellfish (22)(23)(24)(25). The urinary Cd concentrations in our study population were higher than those reported in the third U.S. National Health and Nutrition Survey (geometric mean: 0.37 mg/g creatinine; ref.…”

Section: Discussioncontrasting

confidence: 52%

Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons and DNA Damage in Taiwanese Traffic Conductors

Huang

Chen

Wang

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Exposure to traffic-related air pollutants, including polycyclic aromatic hydrocarbons (PAH) and heavy metals, has been associated with the etiology and prognosis of many illnesses. However, the specific causal agents and underlying mechanisms for different health outcomes remain unclear. The aims of this study were to assess the relations between urinary biomarkers of exposure to PAHs (1-hydroxypyrene-glucuronide, 1-OHPG) and heavy metals (cadmium, Cd; nickel, Ni; arsenic, As; lead, Pb; and copper, Cu) and the effect of their interaction on DNA damage (8-oxo-7,8-dihydro-guanine, 8-oxodG).Methods: We recruited 91 traffic conductors and 53 indoor office workers between May 2009 and June 2011 in Taipei, Taiwan. Postshift urine samples from 2 consecutive days were analyzed for 1-OHPG, Cd, Ni, As, Pb, Cu, and 8-oxodG. To estimate the effects from PAHs and metals on DNA damage, we constructed a linear mixed model adjusted for confounding variables.Results: We found that urinary 1-OHPG and Cd levels were independent predictors of urinary 8-oxodG levels (b ¼ 0.112; P ¼ 0.015 for 1-OHPG; b ¼ 0.138; P ¼ 0.031 for urinary Cd). The joint effect of urinary 1-OHPG and Cd levels was associated with urinary 8-oxodG levels (P ¼ 0.001).Conclusions: Co-exposure to environmental PAHs and Cd could cause oxidative DNA damage. Impact: These findings suggest that the additive interaction between exposure to environmental PAHs and Cd could enhance the burden of oxidative stress. Cancer Epidemiol Biomarkers Prev; 22(1); 102-8. Ó2012 AACR.

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Section: Discussioncontrasting

confidence: 52%

Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons and DNA Damage in Taiwanese Traffic Conductors

Huang

Chen

Wang

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Smoking was very rare among women in this rural population [52••] and we included the results for women as part of our systematic review and meta-analysis. For studies analyzing the same cardiovascular endpoints in the same study population we selected the most recent publication or the publication with the largest sample size, resulting in the exclusion of 5 papers [25, 53–56] and leaving 12 studies. Any discrepancies were resolved by consensus.…”

Section: Methodsmentioning

confidence: 99%

Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review

Téllez-Plaza

Jones

Dominguez-Lucas

et al. 2013

Curr Atheroscler Rep

229

127

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Mounting evidence supports that cadmium, a toxic metal found in tobacco, air and food, is a cardiovascular risk factor. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between cadmium exposure and cardiovascular disease. Twelve studies were identified. Overall, the pooled relative risks (95% confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were: 1.36 (95%CI: 1.11, 1.66), 1.30 (95%CI: 1.12, 1.52), 1.18 (95%CI: 0.86, 1.59), and 1.49 (95%CI: 1.15, 1.92), respectively. The pooled relative risks for cardiovascular disease in men, women and never smokers were 1.29 (1.12, 1.48), 1.20 (0.92, 1.56) and 1.27 (0.97, 1.67), respectively. Together with experimental evidence, our review supports the association between cadmium exposure and cardiovascular disease, especially for coronary heart disease. The number of studies with stroke, HF and PAD endpoints was small. More studies, especially studies evaluating incident endpoints, are needed.

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“…Moreover, epidemiological studies also evidenced that Cd exposure was associated with the chronic diseases, such as diabetes, diabetic nephropathy, hypertension, and peripheral artery disease (Ju, Chen, and Liao 2012).…”

Section: Introductionmentioning

confidence: 99%

Potatoes – A crop resistant against input of heavy metals from the metallicaly contaminated soil

Musilová

Bystrická

Lachman

et al. 2015

International Journal of Phytoremediation

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The objective of our study was to assess the extent of accumulation of cadmium, lead and zinc in potato tubers depending on the concentration of these heavy metals in soil and to evaluate the resistance of 11 cultivars of potato cultivated in 5 localities of the Slovakia against input of these heavy metals into the consumption part of potato. Contents of Cd (Pb, Zn) in soil were 0.94-2.54 (18.03-24.90, 35.71-72.40) mg/kg in soil extract by aqua regia and 0.030-0.188 (0.149-0.356, 0.052-0.238) mg/kg in soil extract by NH4NO3. The contents of Cd, Pb, and Zn were determined in potatoes in extracts of freeze-dried samples and expressed in mg/kg of fresh matter (FM). Determined contents of heavy metals were in the range of ND-0.058 mg Cd/kg FM, 0.020-0.630 mg Pb/kg FM, 1.836-3.457 mg Zn/kg FM, resp. The statistically significant correlation between heavy metal content in soil and its content in potato tubers were confirmed only: cv. Laura - Spissky Stvrtok (Cd), cv. Red Anna - Odorin (Pb) and Marabel, Red Anna - Odorin, cv. Marabel - Belusa, cv. Volumia - Imel (Zn).

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Assessing human exposure risk to cadmium through inhalation and seafood consumption

Cited by 42 publications

References 57 publications

Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons and DNA Damage in Taiwanese Traffic Conductors

Exposure to Heavy Metals and Polycyclic Aromatic Hydrocarbons and DNA Damage in Taiwanese Traffic Conductors

Cadmium Exposure and Clinical Cardiovascular Disease: A Systematic Review

Potatoes – A crop resistant against input of heavy metals from the metallicaly contaminated soil

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