Purpose: We summarized the evidence on the effects of heat and cold exposures on mortality in China. We included studies published on this topic in both Chinese and English, thereby filling a gap in knowledge using data from a country that consists of one-fifth of the world's population.Methods: We conducted a systematic search of peer-reviewed studies on the association between daily mean temperature and mortality published from 2001 up to July 2018. We searched one Chinese database (China National Knowledge infrastructure, http://www.cnki.net) and three English databases (PubMed, Scopus, Web of Science). We converted the effect estimates of heat/cold to rate ratios (RRs) associated with 1 degree increase/decrease beyond the heat/cold reference temperatures. For studies that provided lag-specific estimates, we used both the maximum and minimum of RR estimates. We calculated summary effect estimates for all-cause and cause-specific mortalities, as well as RRs stratified by sex, age, and socioeconomic status. We also investigated patterns of heat and cold adaptation at different latitudes, and at different reference temperatures.Results: In total, 45 articles were included in this systematic review. For every 1 degree temperature increase/decrease beyond reference points, the rate of non-accidental mortality increased by 2% (RR, 1.02; 95% confidence interval (95% CI [1.01-1.02]) for heat and 4% (RR, 1.04; 95% CI [1.03-1.04]) for cold, respectively; the rate of cardiovascular mortality increased 3% ( RR, 1.03; 95% CI [1.03-1.04]) for heat and 6% (RR, 1.06; 95% CI [1.04-1.07]) for cold; the rate of respiratory mortality increased 2% ( RR, 1.02; 95% CI [1.01-1.03]) for heat and 2% (RR, 1.02; 95% CI [1.00-1.04]) for cold; the rate of cerebrovascular mortality increased 2% (RR, 1.02; 95% CI [1.02-1.03]) for heat and 3% (RR, 1.03; 95% CI [1.02-1.04]) for cold. We identified a variation in optimal temperature range related to latitude of the residential area, and differences in people's capability to adapt to heat versus cold.
Conclusion:We found consistent evidence of the association between temperature and mortality, as well as evidence of patterns in human adaptation, and we discussed the implications of our findings.