Assessing health-related quality of life in patients with benign non-toxic goitre

Watt, Torquil; Cramon, Per; Frendl, Daniel

doi:10.1016/j.beem.2014.01.009

Cited by 19 publications

(25 citation statements)

References 46 publications

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“…Nowadays, treatments of BNTs are primarily elected for the HRQoL indications, and therefore, well-controlled studies should be performed to compare the HRQoL effects of various treatment modalities24. Indeed, there are an increasing number of studies using HRQoL as a high priority outcome in the field of thyroid diseases and have reported heterogeneous results.…”

Section: Discussionmentioning

confidence: 99%

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Yue

Wang

et al. 2016

Sci Rep

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This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT. Sensitivity analyses of costs of RFA were performed. At 6-month visit, patients treated with RFA had significantly better HRQoL than patients treated with OT on general health (68.5 versus 66.7, P = 0.029), vitality (71.3 versus 67.5, P < 0.001) and mental health (80.9 versus 79.3, P = 0.038). RFA was more effective than OT in terms of quality-adjusted life-years (QALYs; 0.01QALY/patient) but more expensive (US$823/patient). The probability that RFA would be cost effective at a US$50,000/QALY threshold was 15.5% in China, and it would be increased to 88.4% when price of the RFA device was lowered by 30%. RFA exhibited a significant improvement of HRQoL relative to OT, but is unlikely to be cost effective at its current price in short time.

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Section: Discussionmentioning

confidence: 99%

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Yue

Wang

et al. 2016

Sci Rep

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“…The importance of HRQoL has also increasingly been acknowledged for thyroid disorders by some recent studies [6–9]. To date, hypothyroidism is thought to be the main factor for the increased symptom load and decreased quality of life.…”

Section: Introductionmentioning

confidence: 99%

Autoimmunity affects health‐related quality of life in patients with Hashimoto's thyroiditis

Uysal

Ayhan

2016

The Kaohsiung J of Med Scie

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Hashimoto's thyroiditis (HT) is the most common endocrine disorder leading to hypothyroidism. HT is characterized by the presence of elevated circulating antibodies, especially anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-Tg). In our study, we aimed to reveal the effects of autoimmunity on health-related quality of life of euthyroid HT patients. Patients who were admitted to the Adnan Menderes University Outpatient Clinic were enrolled. The medical records of the patients were surveyed and their demographical data were collected. By using communication data, the patients were invited to our clinic, to inform them about our study and to fill out the health-related quality of life questionnaire. A total of 84 euthyroid HT patients older than 18 years who completed the short form-36 questionnaire, were enrolled. As all patients were euthyroid, there was a significant negative correlation between each domain score and the antibody levels, individually. Patients who had higher anti-TPO and anti-Tg levels had significantly lower quality of life domain scores (p < 0.001). There was statistically no significant correlation between the antibody levels and thyroid function tests (p > 0.05). Additionally, all dimension scores were significantly higher both in the anti-Tg and anti-TPO negative groups, indicating a better quality of life than that in the antibody positive groups. Our study revealed that higher thyroid antibody levels were negatively correlated with life quality scores. Thus, patients who had higher anti-TPO and anti-Tg levels had significantly lower quality of life domain scores. We believe that apart from hypothyroidism, a high antibody level was one of the contributing factors for the development of HT-associated symptoms, leading to a lower quality of life. Other probable contributing factors such as selenium deficiency, thyroid hormone fluctuation, and disease awareness should keep in mind.

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“…In addition, patients may have cosmetic complaints [5][6][7][8][9] as well as reduced overall quality of life (QOL). 10 When warranted, treatment options for goiters depend on symptomatology, goiter size, and patient preference. Available therapeutic options include surgery, radioiodine, and ultrasound-guided interventional ablation (eg, laser and radiofrequency therapy).…”

mentioning

confidence: 99%

“…Studies evaluating the effects of treatment of nontoxic goiters on QOL, using well-validated instruments, are few and show conflicting results. 10 Using generic questionnaires, Short Form Health Survey-36 and EuroQOL-5D questionnaires, 2 studies found no improvements in QOL after thyroid surgery. 19,20 A concern aired regarding these results was the possible low sensitivity of generic questionnaires in general.…”

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confidence: 99%

Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study

et al. 2017

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Assessing health-related quality of life in patients with benign non-toxic goitre

Cited by 19 publications

References 46 publications

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

Autoimmunity affects health‐related quality of life in patients with Hashimoto's thyroiditis

Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study

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