Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Axtell, Andrea L.; Gomari, Fatemeh A.; Cooke, John P.

doi:10.3791/2167-v

Cited by 17 publications

(20 citation statements)

References 12 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Endo‐PAT 2000 (Itamar Medical, Israel) test is a noninvasive, automated, and recognized technique for measuring vascular function that simultaneously assesses both the reactive hyperemia index (RHI), which is indicative of endothelial vasodilator function, and the digital augmentation index (AIx) to indicate arterial stiffness 16 . Endo‐PAT diagnostic system records peripheral arterial tension (PAT) to determine the fingertips pulses volume change before and after unilateral blood flow occlusion by comparing it with the contralateral arm signal.…”

Section: Introductionmentioning

confidence: 99%

Osteocalcin association with vascular function in chronic kidney disease

Guo

Zhou

et al. 2022

J of Clinical Hypertension

View full text Add to dashboard Cite

Osteocalcin (OCN) is a bone-derived and vitamin K dependent hormone that affects energy metabolism and vascular calcification. The relationship between serum OCN and vascular function in patients with chronic kidney disease (CKD) is uncertain. This study investigated the association between serum OCN and vascular function as expressed with reactive hyperemia index (RHI) and augmentation index (AIx) measured by Endo-PAT 2000 device. This cross-sectional analysis was based on 256 pre-dialysis CKD patients who had completed the Endo-PAT 2000 test and serum OCN at the First Center of Chinese PLA Hospital from November 2017 to December 2019. Based on whether the RHI was less than 1.67, the patients were divided into endothelial dysfunction and normal endothelial function groups. Multiple logistic and linear regression were used to analyze the association between OCN and vascular function. Subgroup analyses were performed to examine the effects of OCN on vascular function in different CKD populations. After mul-tivariate adjustment, CKD with low OCN were more likely to have endothelial dysfunction (OR: 0.794; 95%CI: 0.674-0.934; P = .006); on the contrary, patients with high OCN had a higher degree of arterial stiffness (standardized β: 0.174; P = .003). Subgroup analyses showed that higher OCN was associated with severe arterial stiffness but a better endothelial function in young (age < 65 years, P RHI /P AIx@75 = .027/.011), male (P RHI /P AIx@75 = .040/.016), patients with a history of hypertension (P RHI /P AIx@75 = .004/.009) or diabetes (P RHI /P AIx@75 = .005/.005), and in early CKD (P RHI /P AIx@75 = .014/.015). In conclusion, serum OCN correlates with vascular function in CKD patients: beneficial for endothelial function but detrimental to arterial stiffness.

show abstract

Section: Introductionmentioning

confidence: 99%

Osteocalcin association with vascular function in chronic kidney disease

Guo

Zhou

et al. 2022

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…Endothelial function tests will be implemented before mental stress tests at baseline and follow-up time points. An Endo PAT 2000 Machine (Itamar Medical Ltd, Caesarea, Israel) [37] will be used to assess the reactive hyperemia index (RHI). Nitrates or any medications for erectile dysfunction will be discontinued 1 day before each patient's endothelial function test.…”

Section: Endothelial Function Testmentioning

confidence: 99%

The Prognostic Study of Mental Stress-induced Myocardial Ischemia in Coronary Revascularization Patients with Depression/Anxiety: Rationale and Design

Nan

Feng

Wang

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Mental stress induced-myocardial ischemia (MSIMI) frequently occurs in patients with coronary artery disease (CAD), and is even more common in patients with co-occurring CAD and depression/anxiety. MSIMI appears to be a poor prognostic factor for CAD, but existing data on depression/anxiety patients are limited. Methods: This cohort study will consecutively enroll 360 CAD patients between 2023 and 2025. Included subjects will need to have received coronary revascularization and also have depression and/or anxiety at baseline. Two mental stress tests will be carried out in each patient at 1 month and 1 year timelines after coronary revascularization, using Stroop color word tests. MSIMI will be assessed by 99m-Tc-sestamibi myocardial perfusion imaging. The endothelial function will be assessed by EndoPAT. Furthermore, we will dynamically monitor patients' health and mental conditions every 3 months. The mean follow-up time will be 1 year. The primary endpoint is the major adverse cardiac events, a composite of all-cause death, cardiac death, myocardial infarction, stroke, or unplanned revascularization. Secondary endpoints will include overall health and mental conditions. The reproducibility of mental stress combined with myocardial perfusion for detecting MSIMI and comparisons between coronary stenosis and ischemic segments will also be included. Conclusions: This cohort study will provide information on MSIMI outcomes in CAD patients who also have comorbid depression/anxiety after revascularization. In addition, understanding the long-term dynamics of MSIMI and the match between coronary stenosis and ischemia will provide insight into MSIMI mechanisms. Trail Registration: ChiCTR2200055792, 2022.1.20, www.medresman.org.cn;

show abstract

“…Absence of a PAT signal, indicating complete occlusion, is maintained for 5 min and then the cuff is deflated as quickly as possible. The measurement period is continued for an additional 5 min to record post-occlusion responses [56].…”

Section: Peripheral Arterial Tonometrymentioning

confidence: 99%

“…Dysfunctional endothelium can result in increased atherosclerotic plaque formation and diseases of various organ systems [55]. Reactive hyperemia is induced in a patient to elicit changes in peripheral arterial tonometry (PAT) and these values are compared pre-and post-occlusion to produce a PAT ratio [56]. While most studies using EndoPAT ® compare these relative ratios, either within a study subject or between study groups, the device manufacturer provides reference ranges for normal endothelial function and endothelial dysfunction based on RHI scores [57].…”

Section: Overviewmentioning

confidence: 99%

See 1 more Smart Citation

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

View full text Add to dashboard Cite

Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

show abstract

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Cited by 17 publications

References 12 publications

Osteocalcin association with vascular function in chronic kidney disease

Osteocalcin association with vascular function in chronic kidney disease

The Prognostic Study of Mental Stress-induced Myocardial Ischemia in Coronary Revascularization Patients with Depression/Anxiety: Rationale and Design

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Contact Info

Product

Resources

About