Background: The aim of this paper is to explore the disciplinary and topic trends associated with empathy (E) and compassion (C) in the PubMed health-related literature and assess whether they suggest a sufficient basis for understanding empathic and compassionate relationships and communities of care in ways that serve practical ends. Methods: I performed 353 queries on E and C in the PubMed database, searching on E, C, and E AND C alone and with 23 disciplinary and 60 topic terms. I considered the total distribution of results for E, C, and E AND C, the relative distribution of results for E and C, and the relative distributions of results within nursing and medicine because of the importance of E and C to healthcare outcomes. Results: The findings reveal a lack of pragmatic perspective suggested by a) semantic overlap between E and C, b) bias toward the psychological perspective of E and C, and c) lack of significant association between E and C and language/linguistics and emotions and the disciplines and topics critical to them that inform pragmatic understanding.