Assessing Duration of Antihypertensive Effects With Whole-Day Blood Pressure Monitoring

Cheung, Deanna G.; Gasster, Julie L.; Weber, Michael A.

doi:10.1001/archinte.1989.00390090077016

Cited by 19 publications

(2 citation statements)

References 16 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 24-hour ambulatory blood pressure measurement provides a better assessment of treatment response than blood pressure measurements as performed in the clinic. It is relatively independent of the timing of the dose 15 and substantially minimizes the placebo effects. 16 Ambulatory blood pressure measurements have been shown to be reproducible and comparable in accuracy with the measurements obtained with the conventional sphygmomanometer.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Terazosin Dose and Blood Pressure Response in Hypertensive Patients

Achari

Hosmane

Bonacci

et al. 2000

The Journal of Clinical Pharma

View full text Add to dashboard Cite

A double‐blind, randomized, placebo‐controlled, multicenter study was conducted to describe the dose‐response curve for terazosin on blood pressure. A total of 128 patients with mild to moderate essential hypertension (supine diastolic blood pressure, 100 to 114 mmHg) participated in the study. The study consisted of a 4‐week single‐blind placebo lead‐in period and a 14‐week double‐blind treatment period. Patients were randomized in equal numbers to four parallel treatment groups: terazosin 1, 2, and 5 mg; terazosin 2, 5, and 10 mg; terazosin 20, 40, and 80 mg; and placebo. The 24‐hour ambulatory blood pressure measurements were performed at the end of the placebo lead‐in period and at the end of each 4‐week fixed‐dose period. The nonlinear, mixed‐effect model computer program was used to analyze the dose‐response relationship. There was a strong dose‐response relationship between fall in blood pressure and the 1 to 10 mg terazosin dose, as well as a plateauing of response for terazosin doses above 10 mg. The maximum antihypertensive response (Emax) to terazosin was 10.7 mmHg for systolic blood pressure and 8.0 mmHg for diastolic blood pressure. The daily dose of terazosin, which produced 50% of the maximum response (ED50), was 3.0 mg for systolic blood pressure and 1.5 mg for diastolic blood pressure. The results of this study suggest that although some patients may benefit from terazosin doses of greater than 10 mg, doses up to 10 mg will maximize therapeutic benefit for most patients, with acceptable side effects.

show abstract

Section: Discussionmentioning

confidence: 99%

The Relationship between Terazosin Dose and Blood Pressure Response in Hypertensive Patients

Achari

Hosmane

Bonacci

et al. 2000

The Journal of Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Angiotensin converting enzyme (ACE) inhibitors have become established antihypertensive agents and it has been suggested that once-daily dosing, with its improved patient compliance, may be adequate for blood pressure (BP) control [1,2]. To better characterize their effects, particularly evaluating duration of action and early morning rise of BP, we used 24-hour ambulatory monitoring to study therapy with once-daily enalapril/hydrochlorothiazide (E/H) and captopril/hydrochlorothiazide (C/H) in patients with moderate hypertension.…”

mentioning

confidence: 99%

Ambulatory blood pressure monitoring for the evaluation of once-daily ACE inhibition: A comparison study of captopril and enalapril combined with hydrochlorothiazide

Pölnitz

Lorenz

Höfling

1991

Cardiovasc Drug Ther

View full text Add to dashboard Cite

Extreme changes in dietary sodium effect daily variability and level of blood pressure in borderline hypertensive patients

James

Pecker

Pickering

et al. 1994

American J Hum Biol

View full text Add to dashboard Cite

This study examined the effect of large changes in dietary sodium on the average ambulatory blood pressure and its variability in 19 patients with uncomplicated borderline hypertension. Each patient participated in a 16-week protocol that consisted of four 4-week periods of different sodium intake (medium (120-160 mEq/day) during periods 1 and 3 and low (< 40 mEq/day) or high (> 225 mEq/day) during either period 2 or 4. The 24-hour urine sodium during the low and high periods averaged 18 and 327 mEq/day, respectively. Ambulatory blood pressure monitoring was done at the end of the fourth week of the low and high diet periods. During monitoring, pressures were recorded every 15 minutes while awake; in addition, patients kept diaries noting activities, posture, and situation at each measurement. The results show that there was a decline of 16/7 mmHg in the average ambulatory awake systolic and diastolic pressures from the high sodium to low sodium diets. Corresponding casual pressures decreased an average of 15 and 8 mmHg, respectively. In examining the factors associated with ambulatory pressure variability, systolic pressure showed greater variation by activity on a low sodium diet than on the high. The findings suggest that sodium restriction has a variable, but in some cases marked, effect on lowering the ambulatory blood pressure in borderline mildly hypertensive patients and that sodium balance may be important to consider when examining ambulatory blood pressure variability. © 1994 Wiley-Liss, Inc.

show abstract

Assessing Duration of Antihypertensive Effects With Whole-Day Blood Pressure Monitoring

Cited by 19 publications

References 16 publications

The Relationship between Terazosin Dose and Blood Pressure Response in Hypertensive Patients

The Relationship between Terazosin Dose and Blood Pressure Response in Hypertensive Patients

Ambulatory blood pressure monitoring for the evaluation of once-daily ACE inhibition: A comparison study of captopril and enalapril combined with hydrochlorothiazide

Extreme changes in dietary sodium effect daily variability and level of blood pressure in borderline hypertensive patients

Contact Info

Product

Resources

About