Assessing drug-related harm – Authors' reply

Nutt, David; King, Leslie A.; Saulsbury, William; Blakemore, Colin

doi:10.1016/s0140-6736(07)60843-5

Cited by 3 publications

(3 citation statements)

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“…Some neuroscientists have argued that there is no neurobiological justification for the fact that alcohol and tobacco are legal while heroin, cocaine and cannabis are not (Nutt, King, Saulsbury, & Blakemore, 2007). The legal status of these drugs, they argue, is not correlated in any simple way with their effects on brain neurochemistry (Ashcroft, Campbell, & Capps, 2007;Nutt et al, 2007).…”

Section: Addiction Neurobiology and Illicit Drug Policymentioning

confidence: 99%

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Anticipating possible policy uses of addiction neuroscience research

Hall

Carter

2013

Drugs: Education, Prevention and Policy

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Neuroscience research on animals has identified the neurochemical circuitry on which psychoactive drugs of dependence act and produced models of the development of tolerance, elicitation of withdrawal symptoms, and the rapid reinstatement of drug use after abstinence. Human neuroimaging studies have provided support for the hypothesis that similar neurobiological processes are at work in addicted humans. Leading proponents of neurobiological addiction research have argued that it provides strong support for the view that addiction is a chronic brain disease. They also argue that broad acceptance of the model will improve societal attitudes and policies towards addicted persons. We briefly examine the research evidence for the claim that addiction is a chronic relapsing brain disease and discuss the promised advantages of the brain disease model of addiction and the likelihood of their realization. We also discuss the potential costs of social policies advocated on the basis of addiction neuroscience research, namely, advocacy of 'high risk' social policies that are congenial to legal industries that promote the use of addictive commodities; renewed advocacy of legally coerced addiction treatment; and the promotion of research into expensive, high technology, biomedical interventions that aim to treat addiction by directly intervening in 'addicted brains'.

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Section: Addiction Neurobiology and Illicit Drug Policymentioning

confidence: 99%

“…These neuroscientists (e.g. Iversen, 2002;Nutt et al, 2007) have argued that policies towards licit and illicit drugs should better reflect their comparative harmfulness to users.…”

Section: Addiction Neurobiology and Illicit Drug Policymentioning

confidence: 99%

Anticipating possible policy uses of addiction neuroscience research

Hall

Carter

2013

Drugs: Education, Prevention and Policy

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“…Professor David Nutt (2007), also an ACMD member and co-author of a new index of harms table published in The Lancet, advised the Council that ecstasy, LSD and 4MTA should not be Class A drugs.…”

Section: Acmd To Consider Downgrading Ecstasymentioning

confidence: 99%

Legal eye

Eastwood¹

2007

Drugs and Alcohol Today

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Rapid, multianalyte detection of opioid metabolites in wastewater

Kumar

Rana

Geiwitz

et al. 2021

Preprint

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By monitoring opioid metabolites, wastewater-based epidemiology (WBE) could be an excellent tool for real-time information on consumption of illicit drugs. A key limitation of WBE is the reliance on costly laboratory-based techniques that require substantial infrastructure and trained personnel, resulting in long turnaround times. Here, we present an aptamer-based graphene field effect transistor (AptG-FET) platform for simultaneous detection of three different opioid metabolites. This platform provides a reliable, rapid, and inexpensive method for quantitative analysis of opioid metabolites in wastewater (WW). The platform delivers a limit of detection (LOD) 2-3 orders of magnitude lower than previous reports, but in line with the concentrations range (pg/ml to ng/ml) of these opioid metabolites present in real samples. To enable multianalyte detection we developed a facile, reproducible, and high yield fabrication process producing twenty G-FETs with integrated side gate platinum (Pt) electrodes on a single chip. Our devices achieved the simultaneous and selective multianalyte detection of three different metabolites: Noroxycodone (NX), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and Norfentanyl (NF) in wastewater.

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Assessing drug-related harm – Authors' reply

Cited by 3 publications

References 0 publications

Anticipating possible policy uses of addiction neuroscience research

Anticipating possible policy uses of addiction neuroscience research

Legal eye

Rapid, multianalyte detection of opioid metabolites in wastewater

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