Assessing DNA barcodes species discriminating ability and phylogenetic relation within Embelia species

Bajpe, Shrisha Naik; Marulasiddaswamy, K. M.; Ramu, Ramith; Badige, Abhijeeth S.; Rudrappa, Maruthi Katenahally; Kini, Ramachandra Kukkundoor

doi:10.7324/jabb.2022.100304

Cited by 2 publications

(4 citation statements)

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“…(Family Primulaceae), which is an evergreen, long, and smooth shrub known as wild berry or wild tea. It is native to Southern India and China [3]. It is also distributed in evergreen, semi-evergreen, and high humidity forests.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Abdelgawad,

El-Hawary,

Abd El-Kader

et al. 2023

Plants

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Plant secondary metabolites are key components for new, safe and effective drugs. Ethanolic extract of Maesa indica Roxb. Sweet (ME) aerial parts were used for biosynthesis of sustainable green zinc oxide nanoparticles (ZnO NPs) with an average particle size 6.80 ± 1.47 nm and zeta potential −19.7 mV. Both transmission electron microscopy and X-ray diffraction assay confirmed the hexagonal shape of ZnO NPs. Phenolic ingredients in ME were identified using LC-ESI-MS/MS-MRM revealing the identification of chlorogenic acid, gallic acid, caffeic acid, rutin, coumaric acid, vanillin, naringenin, quercetin, ellagic acid, 3.4-dihydroxybenzoic acid, methyl gallate, kaempferol, ferulic acid, syringic acid, and luteolin. The major compound was chlorogenic acid at concentration of 1803.84 μg/g. The antiviral activity of ME, ZnO NPs, and combination of ME with ZnO NPs against coronavirus 229E were investigated. ZnO NPs had superior antiviral effect against coronavirus 229E than ME while their combination showed the highest anti-coronavirus 229E effect, with 50% inhibition concentration (IC50) of 5.23 ± 0.18 µg/mL and 50% cytotoxic concentration (CC50) of 138.49 ± 0.26 µg/mL while the selectivity index (SI) was 26.47. The current study highlighted the possible novel anti-coronavirus 229E activity of green ZnO NPs synthesized from Maesa indica. More studies are needed to further investigate this antiviral activity to be utilized in future biomedical and environmental applications.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Abdelgawad,

El-Hawary,

Abd El-Kader

et al. 2023

Plants

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“…Maesa indica Roxb. Sweet, also known as wild berry or wild tea, is a long, glabrous, evergreen shrub belonging to the family Primulaceae and native to China and Southern India [1]. It can also be found in forests with high humidity, semi-evergreens, and evergreens.…”

Section: Introductionmentioning

confidence: 99%

“…It can also be found in forests with high humidity, semi-evergreens, and evergreens. Numerous phytochemical classes, such as flavonoids, phenolics, saponins, tannins, carbohydrates, fixed oil, and glycosides, have been identified in this plant [1]. Palmitic acid, chrysophanol, glyceryl palmitate, stigmasterol, β-sitosterol, dodecane, maesaquinone, quercetin 3-rhamnoside, rutin, chlorogenic acid, catechin, quercetin, nitrendipine, 2,3dihydroxypropyl octadeca-9,12-dienoate, kiritiquinon, and β-thujone are among the many active ingredients identified in it [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous phytochemical classes, such as flavonoids, phenolics, saponins, tannins, carbohydrates, fixed oil, and glycosides, have been identified in this plant [1]. Palmitic acid, chrysophanol, glyceryl palmitate, stigmasterol, β-sitosterol, dodecane, maesaquinone, quercetin 3-rhamnoside, rutin, chlorogenic acid, catechin, quercetin, nitrendipine, 2,3dihydroxypropyl octadeca-9,12-dienoate, kiritiquinon, and β-thujone are among the many active ingredients identified in it [1,2]. Maesa indica is reported to have many biological properties like anticancer, antidiabetic [2], anti-angiogenic, anti-leishmanial, antioxidant, radical scavenging [2], antibacterial [3], antiviral [4] and anti-coronavirus [5].…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical Elucidation and Effect of Maesa indica (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats

Abdelgawad,

El-Hawary,

El-Kader

et al. 2024

Plants

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Maesa indica (Roxb.) Sweet is one of the well-known traditionally-used Indian plants. This plant is rich in secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, saponins, and carbohydrates. It contains numerous therapeutically active compounds like palmitic acid, chrysophanol, glyceryl palmitate, stigmasterol, β-sitosterol, dodecane, maesaquinone, quercetin 3-rhaminoside, rutin, chlorogenic acid, catechin, quercetin, nitrendipine, 2,3-dihydroxypropyl octadeca-9,12-dienoate, kiritiquinon, and β-thujone. The Maesa indica plant has been reported to have many biological properties including antidiabetic, anticancer, anti-angiogenic, anti-leishmanial, antioxidant, radical scavenging, antibacterial, antiviral, and anti-coronavirus effects. One purpose of the current study was to investigate the leaves’ metabolome via Triple-Time-of-Flight-Liquid-Chromatography-Mass Spectrometry (T-TOF LC/MS/MS) to identify the chemical constituents of the Maesa indica ethanolic extract (ME). Another purpose of this study was to explore the protective effect of ME against potassium dichromate (PD)-induced pulmonary damage in rats. Rats were assigned randomly into four experimental groups. Two different doses of the plant extract, (25 and 50 mg/kg), were administered orally for seven consecutive days before PD instillation injection. Results of our study revealed that ME enhanced cellular redox status as it decreased lipid peroxidation marker, MDA and elevated reduced glutathione (GSH). In addition, ME upregulated the cytoprotective signaling pathway PI3K/AKT. Moreover, ME administration ameliorated histopathological anomalies induced by PD. Several identified metabolites, such as chlorogenic acid, quercetin, apigenin, kaempferol, luteolin, and rutin, had previously indicated lung-protective effects, possibly through an antioxidant effect and inhibition of oxidative stress and inflammatory mediators. In conclusion, our results indicated that ME possesses lung-protective effects, which may be the result of its antioxidant and anti-inflammatory properties.

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Assessing DNA barcodes species discriminating ability and phylogenetic relation within Embelia species

Cited by 2 publications

References 0 publications

Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Phytochemical Profiling and Antiviral Activity of Green Sustainable Nanoparticles Derived from Maesa indica (Roxb.) Sweet against Human Coronavirus 229E

Phytochemical Elucidation and Effect of Maesa indica (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats

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