Assessing dissolution kinetics of powders by a single particle approach

Marabi, A.; Mayor, Guy; Burbidge, Adam; Wallach, Rony; Saguy, I. Sam

doi:10.1016/j.cej.2007.07.081

Cited by 48 publications

(40 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, a dissolution study using sugar spheres, built up mainly of sucrose, proved that the sugar-based pellets possess good water solubility properties (32). Isomalt is also water-soluble, showing 25 g/100 ml solubility at 20 C (10).…”

Section: Dissolution Studies Of Coated Pelletsmentioning

confidence: 99%

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

et al. 2010

View full text Add to dashboard Cite

Abstract. The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustainedrelease pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different ratios of Eudragit® RS30D and Eudragit® RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus. Physical characteristics such as mechanical strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar-and isomalt-type pellet cores demonstrated similar drug release profiles.

show abstract

Section: Dissolution Studies Of Coated Pelletsmentioning

confidence: 99%

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The methodologies used in previous dissolution kinetics measurement studies for calculating the dissolution rates from a set of images are usually not detailed [3,10,21]. These methods consist in measuring the distance between the profiles of one dissolving solid at different times.…”

Section: Measurement Of Dissolution Kinetics By Optical Microscopy Obmentioning

confidence: 99%

“…Mgaidi et al [4] and Singh et al [19] used it for monitoring the evolution of the morphology of sand and succinic acid crystals during dissolution. The temporal studies vary from the measurement of total dissolution time of sucrose crystals in melted sorbitol by Bhandari et al [2] to more complex studies which used optical microscopy for measuring the dissolution rates of several solids, such as those from Marabi et al [3] for the dissolution rates of pure sucrose spherical particles in water, ethylene glycol, and polyethylene glycol, Forny et al [20] for those of milk powder particles in water, and Dorozhkin [10,21] for single crystals of the natural Khibin (Kola) fluorapatite. Prasad et al [22] and Raghavan et al [23,24] have even measured the dependency of dissolution rates of paracetamol and a lactose monohydrate crystals in water depending on the crystal faces considered.…”

Section: Introductionmentioning

confidence: 99%

“…Dissolution is a key phenomenon encountered in various processes, for example for drug delivery, quality control in pharmacology [1] or in the food-processing industry [2,3]. Dissolution also takes part in many chemical processes in the mining industry [4][5][6][7], batteries [8,9], fertilizer production [10], or the recycling industry [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A method for phenomenological and chemical kinetics study of autocatalytic reactive dissolution by optical microscopy. The case of uranium dioxide dissolution in nitric acid media

Marc¹,

Magnaldo²,

Godard³

et al. 2018

EPJ Nuclear Sci. Technol.

View full text Add to dashboard Cite

Abstract. Dissolution is a milestone of the head-end of hydrometallurgical processes, as the stabilization rates of the chemical elements determine the process performance and hold-up. This study aims at better understanding the chemical and physico-chemical phenomena of uranium dioxide dissolution reactions in nitric acid media in the Purex process, which separates the reusable materials and the final wastes of the spent nuclear fuels. It has been documented that the attack of sintering-manufactured uranium dioxide solids occurs through preferential attack sites, which leads to the development of cracks in the solids. Optical microscopy observations show that in some cases, the development of these cracks leads to the solid cleavage. It is shown here that the dissolution of the detached fragments is much slower than the process of the complete cleavage of the solid, and occurs with no disturbing phenomena, like gas bubbling. This fact has motivated the measurement of dissolution kinetics using optical microscopy and image processing. By further discriminating between external resistance and chemical reaction, the "true" chemical kinetics of the reaction have been measured, and the highly autocatalytic nature of the reaction confirmed. Based on these results, the constants of the chemical reactions kinetic laws have also been evaluated.

show abstract

“…According to materials quantity, the studying methods on dissolution can be chiefly divided into two categories, by a single particle [5][6][7][8] and by powders [9][10][11][12]. Many techniques have been applied to quantify dissolution process through characterizing solid or liquid phase properties, such as concentration analysis (titration, ion selective electrode, spectrophotometry, refractometry), chemical composition analysis (Infrared spectrometer, Raman spectrometer, XRD), particle analysis (microscope [6], SEM [8,13], AFM [14]) and so on.…”

Section: Introductionmentioning

confidence: 99%

On‐line monitoring of lithium carbonate dissolution

Sun

Song²,

Wang

et al. 2009

Cryst. Res. Technol.

View full text Add to dashboard Cite

Dissolution of lithium carbonate (Li 2 CO 3 ) in aqueous solution was investigated using three on-line apparatuses: the concentration of Li 2 CO 3 was measured by electrical conductivity equipment; CLD (Chord Length Distribution) was monitored by FBRM (Focused Beam Reflectance Measurement); crystal image was observed by PVM (Particle Video Microscope). Results show dissolution rate goes up with a decrease of particle size, and with an increase in temperature; stirring speed causes little impact on dissolution; ultrasound facilitates dissolution obviously. The CLD evolution and crystal images of Li 2 CO 3 powders in stirred fluid were observed detailedly by FBRM and PVM during dissolution. Experimental data were fitted to Avrami model, through which the activation energy was found to be 34.35 kJ/mol. PBE (Population Balance Equation) and moment transform were introduced to calculate dissolution kinetics, obtaining correlation equations of particle size decreasing rate as a function of temperature and undersaturation.

show abstract

Assessing dissolution kinetics of powders by a single particle approach

Cited by 48 publications

References 47 publications

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

A method for phenomenological and chemical kinetics study of autocatalytic reactive dissolution by optical microscopy. The case of uranium dioxide dissolution in nitric acid media

On‐line monitoring of lithium carbonate dissolution

Contact Info

Product

Resources

About