Assessing Disease Activity in Psoriatic Arthritis: A Literature Review

Abstract

Psoriatic arthritis (PsA) is a multifaceted disease, with a high impact on patients’ psychological and physical well-being. There is increasing recognition that assessment of both clinical aspects of disease and patient identified concerns, such as fatigue, work disability, and treatment satisfaction need to be addressed. Only then can we fully understand disease burden and make well-informed treatment decisions aimed at improving patients’ lives. In recent years, there has been much progress in the development of unidimensional and composite measures of disease activity, as well as questionnaires capturing the patient’s perspective in psoriatic disease. Despite these advances, there remains disagreement amongst clinicians as to which instruments should be used. As a consequence, they are yet to receive widespread implementation in routine clinical practice. This review aims to summarize currently available clinical and patient-derived assessment tools, which will provide clinicians with a practical and informative resource.

Living with arthritis: a “training camp” for coping with stressful events? A survey on resilience of arthritis patients following the COVID-19 pandemic

“…In this view, studies with larger population would be needed to further explore the topic and possibly confirm our results. Moreover, due to the limited number of patients included in our study, we opted to uniform the assessment of disease activity using DAS28-CRP in both RA and PsA with the aim of improving statistical power, although the use of more comprehensive or composite indices would be appropriate in patients with PsA [37]. Another potential limitation is the different modality of requesting to participate to the survey between patients and controls.…”

Product of Investigator Global Assessment and Body Surface Area (IGAxBSA): A practice-friendly alternative to the Eczema Area and Severity Index to assess atopic dermatitis severity in children

“…[9][10][11][12] As such, PGA3BSA is being touted as a potential alternative for the PASI in clinical practice. 14,15 A similar measure for pediatric AD has yet to be evaluated.…”

Singapore chapter of rheumatologists' updated consensus statement on the eligibility for government subsidization of biologic and targeted therapy for the treatment of psoriatic arthritis

“…The evaluation of disease activity in PsA has traditionally been challenging due to its heterogeneity. Physician‐assessed domains such as peripheral arthritis, axial disease, dactylitis, enthesitis, skin and nail disease as well as patient‐reported outcomes such as patient global assessment, quality of life, fatigue, functional or work impairment need to be considered for holistic evaluation …”

“…Physician-assessed domains such as peripheral arthritis, axial disease, dactylitis, enthesitis, skin and nail disease as well as patient-reported outcomes such as patient global assessment, quality of life, fatigue, functional or work impairment need to be considered for holistic evaluation. 25 In our previous consensus process, we recognized that there was no single composite measure that reflected all components of PsA activity that was practical for routine clinical use. We discussed the use of Disease Activity Score in 28 joints (DAS28) and…”