Assessing connectivity despite high diversity in island populations of a malaria mosquito

Bergey, Christina M.; Lukindu, Martin; Wiltshire, Rachel M.; Fontaine, Michaël C.; Kayondo, Jonathan; Besansky, Nora J.

doi:10.1101/430702

Cited by 2 publications

(2 citation statements)

References 89 publications

(84 reference statements)

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“…Our results are consistent with studies of mosquitoes on other oceanic islands (Schmidt et al, 2019;Clarkson et al, 2020). Similar work analyzing anopheline mosquitoes on lacustrine islands in Lake Victoria suggest a much lower degree of genetic isolation (Bergey et al, 2020), which is not surprising considering their geographic proximity to the mainland.…”

Section: São Tomé and Príncipe As Sites For Novel Gem Mosquito Field supporting

confidence: 91%

The origin of island populations of the African malaria mosquito, Anopheles coluzzii

Campos

Hanemaaijer

Gripkey

et al. 2020

Preprint

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Anopheles coluzzii is a major malaria vector throughout its distribution in west-central Africa. Here we present a wholegenome resequencing study of 77 specimens from eight localities, that covers a large part of this species' range, including three islands in the Gulf of Guinea: Bioko, São Tomé and Príncipe. Population genomic analyses encompassed structure of mainland populations, of island populations and connectivity between island and mainland populations. Three genetic clusters were found among mainland populations and genetic distances among all populations fit an isolation-by-distance model. Genomic analyses were applied to estimating the demographic history and ancestry (cross-coalescence) for each island. Taken together with the unique biogeography and history of human occupation for each island they present a coherent explanation underlying contemporary levels of genetic isolation between mainland and island populations and among island populations. We discuss the relation of our findings to the suitability of São Tomé and Príncipe islands as candidate sites for potential field trials of genetic-based malaria control strategies.

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Section: São Tomé and Príncipe As Sites For Novel Gem Mosquito Field supporting

confidence: 91%

The origin of island populations of the African malaria mosquito, Anopheles coluzzii

Campos

Hanemaaijer

Gripkey

et al. 2020

Preprint

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“…As the ortholog of this gene in An. gambiae was recently identified as the target of a selective sweep in populations from Uganda (50), further investigation may be warranted despite the significant challenges of definitively linking candidate targets of natural selection to adaptive consequences (51).…”

Section: Resultsmentioning

confidence: 99%

Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito

Small

Costantini

Sagnon

et al. 2022

Preprint

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Local adaptation results in the formation of ecotypes—conspecific groups with heritable differences that increase fitness to distinct environments. The adaptive significance of ecotypes is widely recognized, but not its genetic basis. Here, focusing on a dominant pan-African malaria vector, we study two co-occurring isomorphic yet karyotypically differentiated populations from Burkina Faso reported to differ in larval ecology and epidemiologically relevant adult behaviors. Since their discovery in the 1990s, further investigation was precluded by lack of modern genomic resources. Here, we used deep whole-genome sequencing and analysis to test the hypothesis that these two morphologically cryptic groups are ecotypes differentially adapted to breeding in natural swamps versus irrigated rice fields. We conclusively demonstrate genome-wide differentiation despite extensive microsympatry, synchronicity, and occasional hybridization. Demographic inference supports a split only ~1,300 years ago, coinciding with the massive expansion of domesticated African rice cultivation, suggesting that a newly abundant anthropogenic habitat may have driven vector diversification. The genomic pattern of differentiation is heterogenous, and we infer that the regions of highest differentiation were under selection during lineage splitting, consistent with local adaptation. The origin of nearly all variation implicated in local adaptation, including chromosomal inversions, substantially predates the ecotype split, suggesting that rapid adaptation to rice fields was fueled mainly by standing genetic variation. Sharp differences in chromosomal inversion polymorphism between ecotypes likely promoted adaptive divergence, by maximizing recombination within the homokaryotypic standard rice ecotype, and suppressing admixture with the other ecotype, which carries inverted arrangements at high frequencies.

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Assessing connectivity despite high diversity in island populations of a malaria mosquito

Cited by 2 publications

References 89 publications

The origin of island populations of the African malaria mosquito, Anopheles coluzzii

The origin of island populations of the African malaria mosquito, Anopheles coluzzii

Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria mosquito

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