Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval

Shakibfar, Saeed; Graff, Claus; Ehlers, Lars Holger; Toft, Egon; Kanters, Jørgen K.; Struijk, Johannes

doi:10.1016/j.compbiomed.2012.01.001

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…T-U wave distortion, T wave alternans, and new-onset ventricular ectopies are further ECG features promoting arrhythmias by increasing the heterogeneity of repolarization across the myocardial wall (13). A composite score of T wave morphology, either alone or in combination with the QT interval, allowed efficient discrimination between normal and abnormal repolarization (29).…”

Section: Discussionmentioning

confidence: 99%

Drug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Study

Girardin¹,

Gex‐Fabry²,

Berney³

et al. 2013

AJP

105

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Section: Discussionmentioning

confidence: 99%

Drug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Study

Girardin¹,

Gex‐Fabry²,

Berney³

et al. 2013

AJP

105

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“…The possibility of ventricular fibrillation due to TdP was previously raised in the earlier study, especially as there was no ECG documentation regarding this deterioration to preclude such a query [22], and over two-thirds of patients (69.4%) were receiving a combination of haloperidol and promethazine (both in an injectable and oral form), with mean doses of 12 mg 5 sd and 75 mg 50 sd, respectively, shortly prior to death ( Table 2). Both of these drugs are known to increase QT interval, with potential risks of ventricular fibrillation [27,28,32]. Compared to the previous mortality study in the same hospitals, it seems that this high contribution of circulatory failure has not improved, since there was no change in the main treatment regime of cheap medication with potential quinidine-like effects has continued to be used, due to limited financial resources in developing countries.…”

Section: Causes Of Mortalitymentioning

confidence: 96%

“…Researchers from different continents have highlighted the potential risks of arrhythmias from the use of antipsychotics with potent cholinergic effects that would likely cause prolongation of the QT interval leading to torsade de pointes (TdP) phenomenon and ventricular fibrillation [27,28]. Arrhythmias are more likely to occur if drug-induced QTc prolongation coexists with other risk factors, such as individual susceptibility, the presence of congenital long QT syndrome low potassium, heart failure, bradycardia and electrolyte imbalance [29].…”

Section: Introductionmentioning

confidence: 99%

Mortality characteristics in Sudan in national psychiatric hospitals: 5-year review of hospital mortality

Osman

Abdalhai

Hassan

et al. 2020

Middle East Curr Psychiatry

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Background Re-auditing mortality of inpatient psychiatric service for a span of time extending to 14 years is scarce in low-resource countries. We are reporting a 5-year mortality study to complete an audit cycle with a previous 9-year mortality research published a few years ago. It serves to improve the standard of care in low-resource settings. Results Out of a total of 7340 (4890 men and 2450 women) admissions to all national psychiatric hospitals in Khartoum over a 5-year period, 36 (23 men and 13 women) patients died while receiving inpatient psychiatric treatment. The mortality rate in this sample was 4.9 (4.7 for men and 5.3 for women). Among all deaths, 30.6% were diagnosed with schizophrenia, while mania constituted 25%, major depression 15% and organic psychosis 11.3%, and 11.1% were considered to be due to alcohol- and/or drug-related disorders. There was no single case of unnatural death in this sample. Twenty patients (55.6%) died following circulatory failure (sudden death), four (11.1%) as a result of an infection, three (8.3%) from renal failure, two (5.6%) secondarily to NMS, two (5.6%) from diabetic complications and four patients as a result of ECT, GIT bleeding, ischaemic heart disease and alcohol complications. Conclusion Circulatory failure and infection are the main causes of death in psychiatric hospitals in Sudan, calling for an intense investigation to resolve these preventable problems.

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“…DiScRi is a diabetes complications screening program in Australia where members of the general public participate in a comprehensive health review consisting of tests including electrocardiogram (ECG), the Ewing battery, retinal scans, peripheral nerve function and assessment of diverse biomarkers associated with risk and early detection of diabetes and cardio-vascular disease. ECG data is crucial for medical applications, as illustrated, for example, by [30][31][32][33]. The DiScRi database is more than ten times larger than [20].…”

Section: Diabetes Screening Research Initiative Databasementioning

confidence: 99%

Predicting cardiac autonomic neuropathy category for diabetic data with missing values

Abawajy

Kelarev

Chowdhury

et al. 2013

Computers in Biology and Medicine

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Cardiovascular autonomic neuropathy (CAN) is a serious and well known complication of diabetes. Previous articles circumvented the problem of missing values in CAN data by deleting all records and fields with missing values and applying classifiers trained on different sets of features that were complete. Most of them also added alternative features to compensate for the deleted ones. Here we introduce and investigate a new method for classifying CAN data with missing values. In contrast to all previous papers, our new method does not delete attributes with missing values, does not use classifiers, and does not add features. Instead it is based on regression and meta-regression combined with the Ewing formula for identifying the classes of CAN. This is the first article using the Ewing formula and regression to classify CAN. We carried out extensive experiments to determine the best combination of regression and meta-regression techniques for classifying CAN data with missing values. The best outcomes have been obtained by the additive regression meta-learner based on M5Rules and combined with the Ewing formula. It has achieved the best accuracy of 99.78% for two classes of CAN, and 98.98% for three classes of CAN. These outcomes are substantially better than previous results obtained in the literature by deleting all missing attributes and applying traditional classifiers to different sets of features without regression. Another advantage of our method is that it does not require practitioners to perform more tests collecting additional alternative features.

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Assessing common classification methods for the identification of abnormal repolarization using indicators of T-wave morphology and QT interval

Cited by 7 publications

References 23 publications

Drug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Study

Drug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Study

Mortality characteristics in Sudan in national psychiatric hospitals: 5-year review of hospital mortality

Predicting cardiac autonomic neuropathy category for diabetic data with missing values

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