Assessing combinatorial effects of HIV infection and former cocaine dependence on cognitive control processes: A functional neuroimaging study of response inhibition

Wakim, Kathryn-Mary; Freedman, Edward G.; Tivarus, Madalina E.; Heinecke, Armin; Foxe, John J.

doi:10.1016/j.neuropharm.2021.108815

Cited by 9 publications

(9 citation statements)

References 57 publications

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“…Therefore, we will discuss the differential outcomes of NHB PLWH who use cocaine and MSM living with HIV who use meth. This is consistent with Dr. Wakim-Takaki's biopsychosocial model of comorbid HIV and CUD (HIV+/CUD+), which documents complex relationships between biological, neurocognitive, and social mechanisms underlying poor outcomes in HIV+/CUD+ patients [15]. In the present review, we generalize this model to CUD and MUD since they have similar complex relationships with cellular, neurocognitive, and social mechanisms [7][8][9][10][16][17][18][19][20].…”

Section: Introductionsupporting

confidence: 84%

Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review

Vines,

Sotelo,

Giddens

et al. 2023

Brain Sciences

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Combined antiretroviral therapy (cART) has greatly reduced the severity of HIV-associated neurocognitive disorders in people living with HIV (PLWH); however, PLWH are more likely than the general population to use drugs and suffer from substance use disorders (SUDs) and to exhibit risky behaviors that promote HIV transmission and other infections. Dopamine-boosting psychostimulants such as cocaine and methamphetamine are some of the most widely used substances among PLWH. Chronic use of these substances disrupts brain function, structure, and cognition. PLWH with SUD have poor health outcomes driven by complex interactions between biological, neurocognitive, and social factors. Here we review the effects of comorbid HIV and psychostimulant use disorders by discussing the distinct and common effects of HIV and chronic cocaine and methamphetamine use on behavioral and neurological impairments using evidence from rodent models of HIV-associated neurocognitive impairments (Tat or gp120 protein expression) and clinical studies. We also provide a biopsychosocial perspective by discussing behavioral impairment in differentially impacted social groups and proposing interventions at both patient and population levels.

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Section: Introductionsupporting

confidence: 84%

Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review

Vines,

Sotelo,

Giddens

et al. 2023

Brain Sciences

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“…High-resolution structural T1 contrast images were acquired using a magnetization prepared rapid gradient echo pulse (MPRAGE) sequence [repetition time (TR) = 2530 ms, echo time (TE) = 2.34 ms, flip angle = 7 degrees, field of view (FOV) = 256 mm, voxel size1 × 1 × 1 mm]. Data were collected as part of a larger study to assess the combined effect of HIV and CD on structural and functional brain measures (Wakim et al, 2021; Wakim et al, 2022).…”

Section: Methodsmentioning

confidence: 99%

“…Similar neurocognitive differences have been observed between chronic cocaine users and HAARTtreated HIV+ patients in neurocognitive domains mediated by fronto-striatal pathways. Both groups show alterations in executive function, verbal memory, and working memory (Madoz-Gúrpide et al, 2011;Walker and Brown, 2018), although data suggest that cocaine-related NCI is attenuated following abstinence (Vonmoos et al, 2014). However, preliminary evidence indicates persistent, compounded NCI in HIV+ individuals with a history of substance dependence despite current abstinence (Martin et al, 2018), suggesting that the substance dependence in HIV+ patients can cause long-lasting neurocognitive changes which do not ameliorate along the typical abstinence-related recovery trajectory.…”

Section: Introductionmentioning

confidence: 97%

“…Previous work indicates that the combination of HIV and CD is associated with functional alteration in brain circuitry mediating high-level cognitive functions, including cognitive control (Wakim et al, 2021; Wakim et al, 2022) and decision making (Bell et al, 2020; Meade et al, 2017). The goal of this study was to examine the effects of HIV on macrostructure and neurocognitive function in cocaine-abstinent individuals with a history of CD.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Hiv Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance

Wakim

Freedman

Tivarus

et al. 2022

Preprint

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Evidence from animal research, postmortem analyses, and MRI investigations indicate substantial morphological alteration in brain structure as a function of HIV or cocaine dependence (CD). Although previous research on HIV+ active cocaine users suggests the presence of deleterious morphological effects in excess of either condition alone, a yet unexplored question is whether there is a similar deleterious interaction in HIV+ individuals with CD who are currently abstinent. To this end, the combinatorial effects of HIV and CD history on regional brain volume, cortical thickness, and neurocognitive performance was examined across four groups of participants: healthy controls, HIV-negative individuals with a history of CD, HIV+ individuals with no history of CD, HIV+ individuals with a history of CD. Our analyses revealed no statistical evidence of an interaction between both conditions on brain morphometry and neurocognitive performance. While descriptively, individuals with comorbid HIV and a history of CD exhibited the lowest neurocognitive performance scores, using Principle Component Analysis of neurocognitive testing data, HIV was identified as a primary driver of neurocognitive impairment. Higher caudate volume was evident in CD+ participants relative to CD- participants. Taken together, these data provide evidence of independent effects of HIV and CD history on brain morphometry and neurocognitive performance in cocaine-abstinent individuals.

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“…However, screening for HAND continues to be di cult and imprecise in the clinical setting. With the cerebral dysfunction thought to appear before changes in white matter and presence of biochemical markers in the cerebrospinal uid (CSF) therefore imaging data may provide more useful information [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Cerebral regional and network abnormalities in HIV-infected with neurocognitive impairments: An fMRI study

Chen

Wei

Tao

et al. 2023

Preprint

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Although the combination antiretroviral treatment (cART) has considerably lowered the risk of HIV associated dementia (HAD), the incidence of neurocognitive impairments(NCI) have not decreased likely due to the insidious and slow progressive nature of HIV infection. Recent studies show that the rest state functional magnetic resonance imaging (rs-fMRI) is a prominent technique in helping the non-invasive analysis of neucognitive impairment. Our study is to explore the neuroimaging characteristics among people living with HIV(PLW-HIV) with or without NCI in terms of cerebral regional and neural network by rs-fMRI, based on the hypothesis that HIV patients with and without NCI have independent brain imaging characteristics. 33 HIV subjects with NCI and 33 HIV subjects without NCI, classified into HIV-NCI group and HIV-control group respectively according to Mini-Mental State Examination(MMSE) results. The fraction amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) were calculated to characterize the cerebral regional and neural network alterations. Finally, the correlation among fALFF/FC values in certain cerebral regions and clinical characteristics were calculated. Compared to the HIV-control group, the fALFF values of bilateral calcarine gyrus, bilateral superior occipital gyrus, left middle occipital gyrus, left cuneus in the HIV-NCI group were increased. The FC values between right superior occipital gyrus and right olfactory cortex, bilateral gyrus rectus, right orbital part of middle frontal gyrus in the HIV-NCI group were increased. The FC values between left hippocampus and bilateral medial prefrontal gyrus, bilateral superior frontal gyrus were decreased. The fALFF values of left cuneus in both two groups was negatively correlated with international HIV dementia scale scores (IHDS) (R=-0.255, P=0.037) ; The fALFF values of left calcarine gyrus in both two groups was negatively correlated with MMSE scores (R=-0.316, P=0.009) ; The FC values between right superior occipital gyrus and right olfactory cortex (R=-0.396, P=0.001) in both two groups was negatively correlated with MMSE scores. Our study showed that the abnormal fMRI patterns in specific brain regions of the occipital cortex, while the defects in brain network mostly associated with prefrontal cortex, were associated with HIV-related cognitive impairment. The variation of fALFF and FC in given brain regions can be used to distinguish HIV subjects with and without cognitive impairment.

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Assessing combinatorial effects of HIV infection and former cocaine dependence on cognitive control processes: A functional neuroimaging study of response inhibition

Cited by 9 publications

References 57 publications

Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review

Neurological, Behavioral, and Pathophysiological Characterization of the Co-Occurrence of Substance Use and HIV: A Narrative Review

Effects of Hiv Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance

Cerebral regional and network abnormalities in HIV-infected with neurocognitive impairments: An fMRI study

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