Assessing cognitive impairment and disability in older adults through the lens of whole brain white matter patterns
Hyun Woong Roh,
Nishant Chauhan,
Sang Won Seo
et al.
Abstract:INTRODUCTIONThis study aimed to explore the potential of whole brain white matter patterns as novel neuroimaging biomarkers for assessing cognitive impairment and disability in older adults.METHODSWe conducted an in‐depth analysis of magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) scans in 454 participants, focusing on white matter patterns and white matter inter‐subject variability (WM‐ISV).RESULTSThe white matter pattern ensemble model, combining MRI and amyloid PET, demonstra… Show more
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