Assessing causal relationship from gut microbiota to heel bone mineral density

Ni, Jun; Yang, Xiaolin; Zhang, Lei; Xu, Qian; Wei, Xin‐Tong; Feng, Guoliang; Zhao, Min; Pei, Yu‐Fang; Zhang, Lei

doi:10.1016/j.bone.2020.115652

Cited by 26 publications

(27 citation statements)

References 50 publications

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“…The experiment found that there was a high abundance of Clostridium in the ovariectomy group and that Ruminococcus belonging to the same order might be the pathogenic bacteria of steroid deficiency-induced osteoporosis (Ma et al, 2020b). The same conclusion was reported in a clinical study by NI et al They identified specific bacteria taxa that regulated bone mass variations via a Mendelian randomization approach and found that Clostridiales and Lachnospiraceae were negatively associated with heel bone density (Ni et al, 2021). In contrast, a clinical study in China by LI et al found a reduced abundance of Lachnospiraceae in individuals with low bone density and a positive correlation between BMD, T-scores, and Lachnospiraceae by high-throughput 16S rRNA gene sequencing of 102 faecal samples (Li et al, 2019a).…”

Section: Firmicutessupporting

confidence: 60%

New Advances in Improving Bone Health Based on Specific Gut Microbiota

Yan

Cai

Guo

2022

Front. Cell. Infect. Microbiol.

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The gut microbiota has been shown to play an important role in the pathogenesis of various diseases, including metabolic diseases, cardiovascular diseases, and cancer. Recent studies suggest that the gut microbiota is also closely associated with bone metabolism. However, given the high diversity of the gut microbiota, the effects of different taxa and compositions on bone are poorly understood. Previous studies demonstrated that the mechanisms underlying the effects of the gut microbiota on bone mainly include its modulation of nutrient absorption, intestinal permeability, metabolites (such as short-chain amino acids), immune responses, and hormones or neurotransmitters (such as 5-hydroxytryptamine). Several studies found that external interventions, such as dietary changes, improved bone health and altered the composition of the gut microbiota. This review summarises the beneficial gut bacteria and explores how dietary, natural, and physical factors alter the diversity and composition of the gut microbiota to improve bone health, thereby providing potential new insight into the prevention of osteoporosis.

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Section: Firmicutessupporting

confidence: 60%

New Advances in Improving Bone Health Based on Specific Gut Microbiota

Yan

Cai

Guo

2022

Front. Cell. Infect. Microbiol.

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“…A recent genome‐wide association study based on Mendelian randomization approach has identified gut bacteria taxa Clostridiales and Lachnospiraceae associated with bone mass variation, suggesting the causal relationship of microbiota and bone development 16 . Consistently, another cross‐sectional study has also shown the correlation between gut microbiota and the development of bone mineral density (BMD) via polygenetic risk scoring analysis 17 .…”

Section: Evidence Of Association Between the Gut Microbiota And Bone Healthmentioning

confidence: 92%

The microbiota-gut-bone axis and bone health

Yang

et al. 2021

Journal of Leukocyte Biology

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The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria, fungi, and viruses, known as the “second gene pool” of the human body. In recent years, the microbiota‐gut‐bone axis has attracted increasing attention in the field of skeletal health/disorders. The involvement of gut microbial dysbiosis in multiple bone disorders has been recognized. The gut microbiota regulates skeletal homeostasis through its effects on host metabolism, immune function, and hormonal secretion. Owing to the essential role of the gut microbiota in skeletal homeostasis, novel gut microbiota‐targeting therapeutics, such as probiotics and prebiotics, have been proven effective in preventing bone loss. However, more well‐controlled clinical trials are still needed to evaluate the long‐term efficacy and safety of these ecologic modulators in the treatment of bone disorders.

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“…Accumulating evidences have revealed that gut microbiota is a critical factor in bone turnover. The analyses via Mendelian randomization approach or polygenetic risk scoring suggest significant association between gut microbiota and human bone mineral density (BMD) in different sites, such as heel or pelvis, by utilizing gut microbiota statistic from genome-wide association study (GWAS) and BMD values from UK biobank cohort ( Cheng et al., 2020 ; Ni et al., 2021 ). Gnotobiotic animal models directly prove gut microbiota as a key regulator of bone turnover.…”

Section: Gut Microbiota and Bone Healthmentioning

confidence: 99%

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

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Assessing causal relationship from gut microbiota to heel bone mineral density

Cited by 26 publications

References 50 publications

New Advances in Improving Bone Health Based on Specific Gut Microbiota

New Advances in Improving Bone Health Based on Specific Gut Microbiota

The microbiota-gut-bone axis and bone health

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

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