Assessing bone status in patients awaiting liver transplantation

Wibaux, Cécile; Legroux-Gérot, Isabelle; Dharancy, Sébastien; Boleslawski, Emmanuel; Declerck, Nicole; Canva, V.; Mathurin, Philippe; Pruvot, François‐René; Cortet, Bernard

doi:10.1016/j.jbspin.2011.03.001

Cited by 43 publications

(20 citation statements)

References 19 publications

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“…In this study, we compared BMD among patients with ESLD caused by NASH, alcoholic cirrhosis, and HCV/HBV. The overall prevalence rates of osteopenia and osteoporosis in our study were found to be 44.4% and 12.7%, respectively, which is consistent with previous reports (1,(17)(18)(19). The prevalence rates of osteopenia/osteoporosis were 67.1% for the HCV/HBV group, 58.8% for the alcoholic cirrhosis group, and 33% for the NASH group.…”

Section: Discussionsupporting

confidence: 91%

Bone Mineral Density in Patients with Nonalcoholic Steatohepatitis among End-Stage Liver Disease Patients Awaiting Liver Transplantation

Boonchaya‐anant

Hardy²,

Borg

et al. 2013

Endocrine Practice

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Section: Discussionsupporting

confidence: 91%

Bone Mineral Density in Patients with Nonalcoholic Steatohepatitis among End-Stage Liver Disease Patients Awaiting Liver Transplantation

Boonchaya‐anant

Hardy²,

Borg

et al. 2013

Endocrine Practice

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“…Existing research shows that iron overload is associated with many diseases, such as hemochromatosis, sickle cell disease, and liver diseases14-16. However, research has also suggested that iron overload is associated with bone metabolism abnormalities, such as osteopenia, osteoporosis, and osteomalacia17-20.…”

Section: Discussionmentioning

confidence: 99%

Regulation of DMT1 on Bone Microstructure in Type 2 Diabetes

Zhang¹,

Meng²,

Yang³

2015

Int. J. Med. Sci.

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Diabetic osteoporosis is gradually attracted people's attention. However, the process of bone microstructure changes in diabetic patients, and the exact mechanism of osteoblast iron overload are unclear. Therefore, the present study aimed to explore the function of DMT1 in the pathological process of diabetic osteoporosis. We build the type two diabetes osteoporosis models with SD rats and Belgrade rats, respectively. Difference expression of DMT1 was detected by using the method of immunohistochemistry and western blotting. Detection of bone microstructure and biomechanics and iron content for each group of samples. We found that DMT1 expression in type 2 diabetic rats was higher than that in normal rats. The bone biomechanical indices and bone microstructure in the rat model deficient in DMT1 was significantly better than that in the normal diabetic model. The loss of DMT1 can reduce the content of iron in bone. These findings indicate that DMT1 expression was enhanced in the bone tissue of type 2 diabetic rats, and plays an important role in the pathological process of diabetic osteoporosis. Moreover, DMT1 may be a potential therapeutic target for diabetic osteoporosis.

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“…Strongest was the association between hyponatremia and liver insufficiency, which is also known to negatively impact bone metabolism, seemingly irreversible despite liver transplantation for end-stage liver disease [27][28][29][30]. Several markers of protein synthesis, clotting factor production, and cholestasis were significantly altered in hyponatremic patients, i.e., elevated levels of ALAT, bilirubin count, cobalamin, GGT, and APTT, while albumin levels were significantly lower.…”

Section: Hyponatremia As a Marker Of Secondary Osteoporosismentioning

confidence: 99%