Assessing biomarkers for post‐surgical wound healing: A meta‐analysis of exosome‐based CircRNA in breast cancer recovery

Abstract

To evaluate the diagnostic potential of exosome‐based circular RNAs (circRNAs) as biomarkers for wound healing in patients after breast cancer surgery, we conducted a comprehensive meta‐analysis of studies that measured exosome‐based circRNA levels in breast cancer patients post‐surgery. Data sources included several biomedical databases up to April 2023. Two independent reviewers extracted the data and assessed study quality. Sensitivity, specificity and diagnostic odds ratios were synthesized using random‐effects model with subgroup analyses performed based on study characteristics. Seventeen studies met the inclusion criteria, encompassing a total of 1234 patients. The pooled sensitivity and specificity of exosome‐based circRNA for detecting wound healing complications were 0.85 (95% CI: 0.77–0.91) and 0.83 (95% CI: 0.78–0.88), respectively. The area under the summary receiver operating characteristic (SROC) curve was 0.90, indicating high diagnostic accuracy. Subgroup analyses revealed that diagnostic performance was consistent across studies of different geographic regions and sample types but indicated potential variability related to patient age and study design. Exosome‐based circRNA profiles exhibited the high diagnostic accuracy for monitoring wound healing in breast cancer post‐operative care. These findings supported the potential utility of circRNA as non‐invasive biomarkers for post‐surgical recovery. However, variability among studies suggested the need for standardized protocols in biomarker measurement. Future research should focus on longitudinal studies to validate the prognostic value of these biomarkers and investigate their role in personalized patient management.