Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique

Fofiu, Renata; Bende, Felix; Popescu, Alina; Şirli, Roxana; Miuţescu, Bogdan; Sporea, Ioan

doi:10.3390/diagnostics11050737

Cited by 8 publications

(13 citation statements)

References 29 publications

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“…A meta-analysis involving 12 studies showed that liver stiffness measured on TE was well correlated with HVPG and demonstrated a sensitivity of 91.2% and specificity of 81.3% in diagnosing clinically significant PH (cut-off values 13.6-18.6 kPa)[ 88 ]. In contrast, despite much less applied than TE, SWE also exhibited encouraging profiles in predicting PH and esophageal varices (AUC: 0.86-0.89)[ 89 - 93 ].…”

Section: Progression Of Diffuse Liver Diseasementioning

confidence: 99%

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

Duan¹,

Jiang²,

Ling³

et al. 2022

WJG

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Hepatic dysfunction represents a wide spectrum of pathological changes, which can be frequently found in hepatitis, cholestasis, metabolic diseases, and focal liver lesions. As hepatic dysfunction is often clinically silent until advanced stages, there remains an unmet need to identify affected patients at early stages to enable individualized intervention which can improve prognosis. Passive liver function tests include biochemical parameters and clinical grading systems ( e.g ., the Child-Pugh score and Model for End-Stage Liver Disease score). Despite widely used and readily available, these approaches provide indirect and limited information regarding hepatic function. Dynamic quantitative tests of liver function are based on clearance capacity tests such as the indocyanine green (ICG) clearance test. However, controversial results have been reported for the ICG clearance test in relation with clinical outcome and the accuracy is easily affected by various factors. Imaging techniques, including ultrasound, computed tomography, and magnetic resonance imaging, allow morphological and functional assessment of the entire hepatobiliary system, hence demonstrating great potential in evaluating hepatic dysfunction noninvasively. In this article, we provide a state-of-the-art summary of noninvasive imaging modalities for hepatic dysfunction assessment along the pathophysiological track, with special emphasis on the imaging modality comparison and selection for each clinical scenario.

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Section: Progression Of Diffuse Liver Diseasementioning

confidence: 99%

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

Duan¹,

Jiang²,

Ling³

et al. 2022

WJG

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“…3). The remaining 61 (67.8%) patients were continued to follow up without hypersplenism upon a median period of 22 months (range, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Clinical Outcome Of the Follow-upmentioning

confidence: 99%

“…The Baveno VI criteria (2015) suggests that transient elastography (TE) can clinically identify significant portal hypertension (CSPH) (1b; A) [16]. On this basis, Fofiu R raised 2D-SWE had a good performance to predict high-risk varices (HRV),) including esophageal varices (EV) and gastric varices (GV) in advanced chronic liver disease (cACLD) [17]. However, no attention has yet been paid to the value of 2D-SWE to predict hypersplenism in WD patients mainly due to the rarity of this disease.…”

Section: Introductionmentioning

confidence: 99%

Liver stiffness assessed by real-time two-dimensional shear wave elastography predicts hypersplenism in patients with Wilson’s disease: a prospective study

Wang

Zhu

et al. 2022

BMC Med Imaging

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Background The current study aimed to explore the value of liver stiffness assessed by two-dimensional real-time shear wave elastography (2D-SWE) to predict hypersplenism occurrence in Wilson’s disease (WD) patients. Methods Ninety WD patients were enrolled in this prospective study between May 2018 and December 2018. Baseline clinical data and ultrasound imaging including 2D-SWE liver stiffness of WD patients were collected. After enrollment, patients had follow-ups for 24 months or until they developed hypersplenism. The hypersplenism risk factors were determined using Cox regressions and receiver operating characteristic curves (ROC). Results Twenty-nine (32.2%) patients developed hypersplenism. Age, portal vein diameter, and liver stiffness were independent hypersplenism risk factors in WD patients. The cutoff value of liver stiffness to predict hypersplenism was 10.45 kPa, with sensitivity and specificity of 75.9% and 73.8%, respectively. Patients were divided into two groups according to liver stiffness: ≥ 10.45 kPa (57.9% with hypersplenism) or < 10.45 kPa (13.5% with hypersplenism). The median time between enrollment and hypersplenism development was 15 months vs. 22 months (p < 0.001) for the two groups, respectively. Conclusion The measurement of liver stiffness by 2D-SWE can be a reliable hypersplenism predictor in WD patients. Therefore, dynamic monitoring of WD patients using 2D-SWE is crucial for the early diagnosis of hypersplenism.

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“…Elasticity is illustrated as a color-coded elastogram, enabling both a qualitative and quantitative LS estimation. Several studies ascertained the usefulness of 2D-SWE in assessing the stiffness of different organs such as the liver, spleen, or thyroid [ 5 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Non-Invasive Ultrasound-Based Assessment of Liver Viscosity in a Healthy Cohort

et al. 2022

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Liver fibrosis is the most significant prognostic factor in chronic liver disease (CLD). Clinical practice guidelines recommend the use of non-invasive techniques, such as two-dimensional shear-wave elastography (2D-SWE), to assess liver stiffness as a marker of fibrosis. Several other factors influence liver stiffness in addition to liver fibrosis. It is presumed that changes due to necro-inflammation modify the propagation of shear waves (dispersion). Therefore, new imaging techniques that investigate the dispersion properties of shear waves have been developed, which can serve as an indirect method of measuring liver viscosity (Vi PLUS). Defining the reference values in healthy subjects among different age groups and genders and analyzing the factors that influence these values is essential. However, published data on liver viscosity are still limited. This is the first study that aimed to assess the normal range of liver viscosity values in subjects with healthy livers and analyze the factors that influence them. One hundred and thirty-one consecutive subjects with healthy livers were enrolled in this prospective study. The results showed that Vi PLUS is a highly feasible method. Liver stiffness, age and BMI influenced the liver viscosity values. The mean liver viscosity by Vi PLUS in subjects with healthy livers was 1.59 Pa·s.

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Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique

Cited by 8 publications

References 29 publications

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

Noninvasive imaging of hepatic dysfunction: A state-of-the-art review

Liver stiffness assessed by real-time two-dimensional shear wave elastography predicts hypersplenism in patients with Wilson’s disease: a prospective study

The Non-Invasive Ultrasound-Based Assessment of Liver Viscosity in a Healthy Cohort

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