Assessing anxiety and its correlates in amyotrophic lateral sclerosis: The state‐trait anxiety inventory

Siciliano, Mattia; Trojano, Luigi; Trojsi, Francesca; Monsurrò, Maria Rosaria; Tedeschi, Gioacchino; Santangelo, Gabriella

doi:10.1002/mus.26475

Cited by 24 publications

(17 citation statements)

References 104 publications

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“…Patients' psychological state may thus be primarily driven by the knowledge of the diagnosis rather than by its physical consequences, in terms of disability. Bulbar symptoms were positively correlated with anxiety, in line with some but not all studies ( 40 ).…”

Section: Discussionsupporting

confidence: 88%

Longitudinal Study of Cognitive and Emotional Alterations in Amyotrophic Lateral Sclerosis: Clinical and Imaging Data

et al. 2021

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Objectives: Extra-motor manifestations occur in 50% of patients with amyotrophic lateral sclerosis (ALS). These mainly concern cognition, emotional processing and behavior. Depression and anxiety are less frequent. Little is known about how these manifestations change as the disease progresses. Similarly, although cortical thinning has been well-documented at disease onset, there are scant data about cortical thinning over time and how this correlates with extra-motor manifestations. The present study therefore assessed cognitive, emotional and psychological state and cortical thinning in a group of patients with ALS at baseline and after a follow-up period.Methods: We assessed executive functions, facial emotion recognition, depressive and anxious symptoms, and cortical thinning in 43 patients with ALS at baseline, comparing them with 28 healthy controls, and 21 of them 9 months later. We looked for links among the extra-motor manifestations and correlations with cortical thickness.Results: At baseline, patients had poor executive function and recognition of complex emotions from the eyes, and more anxious and depressive symptoms than controls. At follow-up, only inhibition abilities had worsened. Cortical thinning was observed in bilateral pre-central regions and other parts of the cerebral cortex at baseline. Over time, it worsened in motor and extra-motor areas. Executive functions correlated with thinning in the middle and inferior frontal gyrus and orbitofrontal cortex.Conclusions: During follow-up, there was little deterioration in extra-motor manifestations and psychological state, despite continuing cortical thinning. Patients with affective Theory of Mind (ToM) changes seemed less depressed than the others. Impaired mental flexibility was subtended by prefrontal regions with cortical thinning.

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Section: Discussionsupporting

confidence: 88%

Longitudinal Study of Cognitive and Emotional Alterations in Amyotrophic Lateral Sclerosis: Clinical and Imaging Data

et al. 2021

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“…A recent meta-analysis reported that the STAI-T demonstrated high reliability (α = 0.87–0.93) and differentiated between the general population and people with anxiety [ 35 ]. Similarly, recent studies in non-English-speaking countries reported highly satisfactory reliability coefficients for the STAI-T, for example, Iran: α = 0.86 [ 36 ]; Italy: α = 0.92 [ 37 ]. Padmanabhannuni and colleagues [ 38 ] reported very satisfactory estimates of internal consistency for the STAI-T when used with South African respondents (α = 0.91, ω = 0.91).…”

Section: Methodsmentioning

confidence: 68%

The Beneficial Effects of Professional Identity: The Mediating Role of Teaching Identification in the Relationship between Role Stress and Psychological Distress during the COVID-19 Pandemic

Pretorius

Padmanabhanunni

2022

IJERPH

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At the start of the COVID-19 pandemic, teachers and students rapidly transitioned to remote teaching and learning. In South Africa, this initial transition was followed by periods of reopening and closing of schools during the various waves of the pandemic. When schools were reopened, rotational schooling was implemented, with students attending in shifts. All this change created a climate of uncertainty for teachers. The current study investigates the relationship between role stress and indices of psychological distress, as well as the potential mediating role of teaching identification in this relationship, using a cross-sectional survey design. Participants (n = 355) were school teachers in South Africa who completed the Role Stress Questionnaire, the Professional Identification Scale, the trait scale of the State-Trait Anxiety Inventory, and the Beck Hopelessness Scale during the second wave of the pandemic (May–July 2021). The results of a structural equation analysis indicate significant positive direct effects of role conflict and ambiguity on anxiety and hopelessness, as well as significant negative direct effects of teaching identification on anxiety and hopelessness. In addition, teaching identification was found to mediate the effect of role conflict and ambiguity on anxiety and hopelessness. The demonstrated role of teaching identification has implications that suggest the importance of leadership and supervisory support, as well as enhancing the societal value of teaching as a profession.

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“…23 Antidepressants are also indicated for anxiety disorders 24 including agoraphobia and panic disorder, the two most common anxiety disorders in patients with ALS. 25 Nonetheless, there is a significant positive correlation between the symptoms of depression and the use of antidepressants, 26 and a previous study on 80 patients with ALS showed that a majority of them taking antidepressants receive them for the treatment of depression. 27 The risk of being prescribed antidepressants in our study seems to be closely related to the fact that they are the treatment of choice for depression.…”

Section: Discussionmentioning

confidence: 97%

“…Low‐dose mirtazapine can be used to treat insomnia 22 and anorexia 23 . Antidepressants are also indicated for anxiety disorders 24 including agoraphobia and panic disorder, the two most common anxiety disorders in patients with ALS 25 . Nonetheless, there is a significant positive correlation between the symptoms of depression and the use of antidepressants, 26 and a previous study on 80 patients with ALS showed that a majority of them taking antidepressants receive them for the treatment of depression 27 …”

Section: Discussionmentioning

confidence: 99%

National prescription patterns of antidepressants among patients with amyotrophic lateral sclerosis: An analysis of the Korean National Health Insurance database

et al. 2022

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Introduction/Aims: The current status of antidepressant use in patients with amyotrophic lateral sclerosis (ALS), such as the prevalence and factors associated with it, has not been systematically investigated. We aimed to analyze the prevalence and patterns of antidepressant prescriptions in patients with ALS and depression, and to identify factors associated with antidepressant prescriptions after the diagnosis of ALS. Methods:The data of patients with ALS and the prescription of antidepressants were retrieved from the Korean National Health Insurance claims data. A multivariate logistic regression model was used to identify factors associated with antidepressant prescriptions.Results: In total, 533 of 2955 patients had depressive disorders, and 426 were prescribed antidepressants. Selective serotonin reuptake inhibitors and tricyclic antidepressants were the most frequently prescribed drugs. Adjusted odds ratios (ORs) were 1.379 for the prescription of antidepressants in females. For various age groups, compared with those aged 80 years and older, adjusted ORs were 1.889 for those in their 70s, 2.319 for those in their 60s, 2.872 for those in their 50s, 2.854 for those in their 40s, and 3.363 for those under 40 years of age. Adjusted ORs were 1.662 for patients with a history of a psychiatric disorder and 1.861 for those with a history of psychiatric pharmacotherapy (all P < .05).Discussion: Most patients with ALS who had depression received antidepressant prescriptions. In young females with a previous psychiatric disorder or pharmacotherapy, an in-depth evaluation for a depressive disorder should be performed.

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Assessing anxiety and its correlates in amyotrophic lateral sclerosis: The state‐trait anxiety inventory

Cited by 24 publications

References 104 publications

Longitudinal Study of Cognitive and Emotional Alterations in Amyotrophic Lateral Sclerosis: Clinical and Imaging Data

Longitudinal Study of Cognitive and Emotional Alterations in Amyotrophic Lateral Sclerosis: Clinical and Imaging Data

The Beneficial Effects of Professional Identity: The Mediating Role of Teaching Identification in the Relationship between Role Stress and Psychological Distress during the COVID-19 Pandemic

National prescription patterns of antidepressants among patients with amyotrophic lateral sclerosis: An analysis of the Korean National Health Insurance database

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