Assessing amyloid PET positivity and cognitive function in Down syndrome to guide clinical trials targeting amyloid
Sophia Krasny,
Cynthia Yan,
Sigan L. Hartley
et al.
Abstract:INTRODUCTIONTrisomy 21, or Down syndrome (DS), predisposes individuals to early‐onset Alzheimer's disease (AD). While monoclonal antibodies (mAbs) targeting amyloid are approved for older AD patients, their efficacy in DS remains unexplored. This study examines amyloid positron emission tomography (PET) positivity (A+), memory function, and clinical status across ages in DS to guide mAb trial designs.METHODSCross‐sectional data from the Alzheimer Biomarker Consortium–Down Syndrome (ABC‐DS) was analyzed. PET am… Show more
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