Assessing 5-year incidence rates and determinants of osteoporotic fractures in primary care

Objectives: To estimate the prevalence and incidence of epilepsy in Italy using a national database of general practitioners (GPs). Methods: The Health Search CSD Longitudinal Patient Database (HSD) has been established in 1998 by the Italian College of GPs. Participants were 700 GPs, representing a population of 912,458. For each patient, information on age and sex, EEG, CT scan, and MRI was included. Prevalent cases with a diagnosis of ‘epilepsy' (ICD9CM: 345*) were selected in the 2011 population. Incident cases of epilepsy were identified in 2011 by excluding patients diagnosed for epilepsy and convulsions and those with EEG, CT scan, MRI prescribed for epilepsy and/or convulsions in the previous years. Crude and standardized (Italian population) prevalence and incidence were calculated. Results: Crude prevalence of epilepsy was 7.9 per 1,000 (men 8.1; women 7.7). The highest prevalence was in patients <25 years and ≥75 years. The incidence of epilepsy was 33.5 per 100,000 (women 35.3; men 31.5). The highest incidence was in women <25 years and in men 75 years or older. Conclusions: Prevalence and incidence of epilepsy in this study were similar to those of other industrialized countries. HSD appears as a reliable data source for the surveillance of epilepsy in Italy. i 2014 S. Karger AG, Basel

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“…The validity of the HSD data for conducting epidemiological studies has been confirmed elsewhere [8,9,10,11,12,13,14,15]. …”

Section: Methodsmentioning

confidence: 75%

Prevalence and Incidence of Epilepsy in Italy Based on a Nationwide Database

Giussani

Cricelli²,

Mazzoleni³

et al. 2014

Neuroepidemiology

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“…1 [23][24][25][26]. The date of the first recorded HDS of osteoporotic fracture was considered as the "entry date" of follow-up.…”

Section: Cohort Selectionmentioning

confidence: 99%

Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures

et al. 2012

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Summary There is evidence that the use oral bisphosphonates can lead to osteronecrosis of the jaws (ONJ). Although the occurrence of ONJ appears rare among oral bisphosphonates (BPs) users, it is important to know that it exists and can be opportunely minimized. Introduction The purpose of this study is to evaluate the association between BPs prescribed for the secondary prevention of osteoporotic fractures and the occurrence of ONJ. Methods An Italian record linkage claims database with a target population of around 18 million individuals (6 million over 55 years of age) constituted the data source. We conducted a nested case-control study within a cohort of individuals aged 55+years old, who were discharged from hospitals with a primary diagnosis of incident osteoporotic fracture. The date related to the discharge diagnosis of ONJ was the index date. Conditional logistic regression for matched data was fitted to estimate the odds ratio (OR) along with 95 % confidence intervals (95 % CI) for the likely association between use of BPs and the risk of ONJ. Results Any one of the 61 ascertained cases of ONJ (incidence rate, 36.6 per 100,000 person-years) was matched to 20 controls for a total of 1120 controls. When the exposure to BPs was modeled according to recency (i.e., exposure time window prior to the index date) of use, the adjusted OR (95 % CI) for current users was 2.8 (1.3-5.9) against never users. The cumulative use of BPs has shown to increase the incidence of ONJ among patients with primary osteoporotic fractures, although not statistically significant risk has been observed. Conclusions Although the risk of BP-related ONJ appears low in non-oncological indications, it is important to be aware that it exists and to know how it may be predicted and possibly minimized.

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“…Data are coded using internationally recognized codes, such as those from the ninth version of the International Classification of Disease, Clinical Modification (ICD-9-CM) for medical diagnoses and the Anatomical Therapeutic Chemical (ATC) classification system for drugs. The research validity of the HSD data has been confirmed elsewhere [17][18][19][20][21][22].…”

Section: Data Sourcementioning

confidence: 92%