Assesment of perfusion in glial tumors with arterial spin labeling; comparison with dynamic susceptibility contrast method

Advances in Magnetic Resonance Imaging and Positron Emission Tomography Imaging for Grading and Molecular Characterization of Glioma

“…Both measures on DSC (rCBV and rCBF) and on ASL (rSI, rCBF and CBF) were significantly higher in high-grade gliomas than low-grade gliomas (p<0.001). [31] There was a high correlation between rCBV measured on DSC and ASL-rCBF (r=0.81, p<0.001). [31] Additional studies have supported that ASL measures including relative signal intensity and rCBF are significantly different between low-and high-grade gliomas such that they may be useful in characterizing tumor grade non-invasively.…”

“…[31] There was a high correlation between rCBV measured on DSC and ASL-rCBF (r=0.81, p<0.001). [31] Additional studies have supported that ASL measures including relative signal intensity and rCBF are significantly different between low-and high-grade gliomas such that they may be useful in characterizing tumor grade non-invasively. [32,33] MR Spectroscopy Proton MR spectroscopy ( 1 H-MRS) evaluates metabolites including N-acetylaspartate (NAA), choline (Cho) and creatine (Cre), lactate (if there is anaerobic metabolism) and lipids (with cellular breakdown secondary to necrosis).…”

Correlation of diffusion tensor and dynamic susceptibility contrast MRI with DNA ploidy and cell cycle analysis of gliomas

“…Several later studies reported similar results [20,21]. Apart from that, rCBV measurements provided the best sensitivity and specificity to predict tumour recurrence and survival time in high-grade glioma patients [22].…”

Differences In High-Intensity Signal Volume Between Arterial Spin Labeling And Contrast-Enhanced T1-Weighted Imaging May Be Useful For Differentiating Glioblastoma From Brain Metastasis

“…It is well known that ASL signal intensity is strongly correlated with tumor vascularity, allowing histopathological tumor diagnosis and grading (9,10,26). The extensive tumor angiogenesis associated with GBM (neovascularization) results in vascular abnormalities such as microvessel proliferation, endothelial hyperplasia, vessel dilation, and high vessel tortuosity.…”