Assembly of the Eukaryotic Ribosome

Abstract

Originally published in: Protein Synthesis and Ribosome Structure. Edited by Knud H. Nierhaus and Daniel N. Wilson. Copyright © 2004 Wiley‐VCH Verlag GmbH & Co. KGaA Weinheim. Print ISBN: 3‐527‐30638‐1 The sections in this article are Introduction Why so many RRP s? (Pre‐)ribosome Assembly, the Proteomic Era Ribosomal RNA Processing, Getting there… Ribosomal RNA Modification: A Solved Issue? Ribose Methylation, Pseudouridines Formation and the sno RNA s The Emergence of the sno RNA s Non‐ribosomal RNA Substrates for the sno RNA s Possible Function(s) of RNA Modifications Base Methylation U3 sno RNP , the ‘ SSU Processome’, and the Central Pseudoknot Sno RNA Synthesis and Intranuclear Trafficking Sno RNA s Synthesis Non‐core sno RNP Proteins Required for sno RNA Accumulation Interactions between Cleavage Factors and Core sno RNP Proteins Sno RNA s Trafficking CB / NB are Conserved Sites of Small RNP Synthesis Ribosome Intranuclear Movements and Ribosome Export The Cytoplasmic Phase of Ribosome Maturation Regulatory Mechanisms, all along Outlook Conclusions Useful WWW links Acknowledgements