Assembly of multifunction dyes and heat shock protein 90 inhibitor coupled to bovine serum albumin in nanoparticles for multimodal photodynamic/photothermal/chemo-therapy

Combined effect of heat shock protein inhibitor geldanamycin and free radicals on photodynamic therapy of prostate cancer

“…When LNCaP cells were treated with AIZAH NPs upon 808 nm laser irradiation, almost all of the LNCaP cells were killed, indicating that the combination of free radicals and 17-AAG enhanced the anti-tumor efficacy of PDT. 21,46 By ELISA analysis, 17-AAG with PDT (IZAH NPs + NIR) and free radicals and 17-AAG combined with PDT (AIZAH NPs + NIR) after incubating LNCaP cells, Hsp90, AR, and survivin were significantly reduced. This result further indicated that the heat shock protein inhibitor (17-AAG) can upregulate and downregulate Hsp90, AR, and survivin to a certain extent and enhance the efficacy of PDT.…”

“…17,18 In addition, the PDT process induces the expression of pro-survival and angiogenic signaling molecules, thereby reducing the efficacy of PDT. 19,20 According to our previous work 21 and others, 22 heat shock protein inhibitors (geldanamycin, 17-AAG) can block the overexpression of Hsp90 and its client proteins such as anti-apoptotic proteins (survivin) 23 and androgen receptor (AR), 24,25 thereby reducing the heat resistance of cancer cells, improving the efficacy of PDT, and promoting the apoptosis of prostate cancer cells. Therefore, the combination of oxygen-independent free radicals and Hsp90 inhibitors accompanied with PDT nanosystems can be a potential approach to optimize and enhance the efficacy of PDT under normoxic and hypoxic conditions.…”

Nanomedicine potentiates mild photothermal therapy for tumor ablation

“… Strategy Nanomedicine Therapeutic agent Target Therapeutic temperature Ref. Small molecular inhibitors Qu-Fe II P Quercetin HSP70 45 °C [29] Mn-ICG@pHis-PEG/GA GA HSP90 ∼43 °C [30] Smart albumin-based theranostic nanoagent (HSA/dc-IR825/GA) GA HSP90 < 45 °C [31] Thermosensitive GOx/ICG/GA liposomes (GOIGLs) GA HSP90 41∼42 [22] GO–GA-polymer scaffold GA HSP90 45 °C [32] Bi 2 Se 3 hollow nanocubes (HNC-s-s-HA/GA) GA HSP90 ∼ 43 °C [33] Hollow mesoporous carbon spheres (HMCS-PEG-GA) GA HSP90 43 °C [34] Bovine serum albumin/canine dye 7/geldanamycin nanoparticles (BSA/Cy7-SQ/GM) GM HSP90 43 °C [35] HSP90 inhibitor-delivered flowerlike short-wave infrared nanoprobe (Lu:Nd@NiS 2 -EGCG) Epigallocatechin gallate (EGCG) HSP90 45 °C [18] Boron-based multifunctional nanoplatform (Dox-17AAG@B-PEG-cRGD) 17AAG ...…”

Recent Advances in Bio‐Compatible Oxygen Singlet Generation and Its Tumor Treatment

“…[282,283] On the other hand, ROS produced between PDT can destroy heat shock proteins, thus reducing their protective effect on tumor cells during PTT. [284] Nano covalent organic frameworks are a new kind of porous materials suitable for carrying PSs and photothermal agents at the same time. Guan et al [278] successfully prepared a dual-mode PDT/PTT nano-drug delivery system by using step-by-step bond defect functionalization.…”