Assembly of a model hydrophobic drug into cationic bilayer fragments

Vieira, Débora Braga; Otalora, Luis F. Pacheco; Carmona-Ribeiro, Ana Maria

doi:10.1016/j.jcis.2005.06.046

Cited by 32 publications

(48 citation statements)

References 43 publications

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“…7). The sonicated bilayer fragments are also polydisperse, but have mean hydrodynamic sizes around 90 nm (Vieira et al 2006;Rozenfeld et al 2011).…”

Section: Detecting Dodab Bicelles By Esrmentioning

confidence: 99%

“…Versatile DODAB membranes have been used as nucleic acid (Silva et al 2011) and hydrophobic drug carriers Vieira et al 2006), as templates for polymerization and deposition of materials (Hubert et al 2000), as biomimetic particles (Rosa et al 2008), as microbicidal agents (Ragioto et al 2014) and as vaccine adjuvants (Rozenfeld et al 2012;Aps et al 2016). Similarly, highly fusogenic diC14-amidine membranes (Oliveira et al 2012) have successfully delivered nucleic acids (El Ouahabi et al 1996;Ruysschaert et al 1994) and stimulated the formation of immune responses (Tanaka et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Structural insights on biologically relevant cationic membranes by ESR spectroscopy

et al. 2017

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Cationic bilayers have been used as models to study membrane fusion, templates for polymerization and deposition of materials, carriers of nucleic acids and hydrophobic drugs, microbicidal agents and vaccine adjuvants. The versatility of these membranes depends on their structure. Electron spin resonance (ESR) spectroscopy is a powerful technique that employs hydrophobic spin labels to probe membrane structure and packing. The focus of this review is the extensive structural characterization of cationic membranes prepared with dioctadecyldimethylammonium bromide or diC14-amidine to illustrate how ESR spectroscopy can provide important structural information on bilayer thermotropic behavior, gel and fluid phases, phase coexistence, presence of bilayer interdigitation, membrane fusion and interactions with other biologically relevant molecules.

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“…7). The sonicated bilayer fragments are also polydisperse, but have mean hydrodynamic sizes around 90 nm (Vieira et al 2006;Rozenfeld et al 2011).…”

Section: Detecting Dodab Bicelles By Esrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

et al. 2017

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“…The interaction between MCZ and DODAB BF was also evaluated from determination of BF loading capacity and effects of drug-to-lipid molar proportion (MP) on particle size, zeta potential and gel-to-liquid-crystalline phase transition (T m ). 254 DODAB BF solubilized MCZ over a range of MP. BF loading capacity was 0.5 mM MCZ at 5 mM DODAB.…”

Section: Nanomedicines Based On Lipidsmentioning

confidence: 97%

“…At MP above 1:10, T m decreases, showing MCZ insertion into the DODAB bilayer. 254 However, the drug is expelled from the bilayer core upon lowering temperature. Minimal fungicidal concentrations against C. albicans are synergically reduced by 10 times for drug/BF.…”

Section: Nanomedicines Based On Lipidsmentioning

confidence: 99%

“…Minimal fungicidal concentrations against C. albicans are synergically reduced by 10 times for drug/BF. 254 For AB in DODAB BF, experiments for evaluation of the therapeutic activity and nephrotoxicity were also performed. The formulation is therapeutically effective in vivo despite its low drug-to-lipid molar ratio 197 and exhibits very low nephrotoxicity due to the low AB dose.…”

Section: Nanomedicines Based On Lipidsmentioning

confidence: 99%

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Biomimetic Systems in Nanomedicine

Carmona-Ribeiro¹

2014

Frontiers in Nanobiomedical Research

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Mimicking Nature has been a major source of inspiration for producing novel pharmaceutical formulations with improved therapeutic index and reduced toxicity. In Nature, the self-assembly of biomolecules driven by intermolecular interactions leads to highly functional, nanosized biological machines. Novel directions for drug and vaccine delivery to cure or prevent disease somehow have to copy Mother Nature wisdom. In this chapter, smart nanocarriers produced from the self-assembly of biocompatible polymers, lipids or hybrid nanoparticles (NPs) are presented and some of their applications in antimicrobial chemotherapy, drug and vaccine delivery discussed. Self-Assembly and Intermolecular InteractionsWeak intermolecular interactions are important for the rational design of novel biomimetic materials. Main weak interactions are the van der Waals interaction (ion-dipole, dipole-dipole, dipole-induced dipole interactions, induced-dipole induced-dipole), the electrostatic interaction, the hydrogen bonds, the hydrophobic interactions and the steric repulsion. 1,2 The weak but cooperative hydrogen bonding between the two strands of double-stranded DNA is a wise approach used by Nature to keep the strands together without hampering replication and transcription. 3 The repulsion between nonpolar Handbook of Nanobiomedical Research Downloaded from www.worldscientific.com by UNIVERSITY OF BIRMINGHAM LIBRARY -INFORMATION SERVICES on 03/21/15. For personal use only.

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Surfactants and Detergents

López-Mahı́a

Muniategui-Lorenzo

Prada‐Rodríguez

2005

Encyclopedia of Analytical Science

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He has worked extensively on the characterization and spectroscopy of surfactant monolayers and supramolecular assemblies. His publication list includes 36 articles in international journals and 19 patents. Dr. Dutta has been the recipient of several international postdoctoral fellowships in Japan, Canada and the United States. Having started his career in product development and innovations with Unilever he later moved into agrochemicals and worked as the Head of Global Formulations with United Phosphorus Limited and Indofil Industries. Presently, he works as a vice president (R&D) with the surfactant major, India Glycols Limited. His research interests continue to be in the areas of colloidal chemistry, novel surfactants, self-assembled nanostructures, and bio-inspired and bio-mimetic supramolecular systems.

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Assembly of a model hydrophobic drug into cationic bilayer fragments

Cited by 32 publications

References 43 publications

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

Structural insights on biologically relevant cationic membranes by ESR spectroscopy

Biomimetic Systems in Nanomedicine

Surfactants and Detergents

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