Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones

Abstract

A variety of cellular reactions mediated by interactions among proteins and nucleic acids requires a series of proteins called molecular chaperones. The viral genome encodes relatively few kinds of viral proteins and, therefore, host-derived cellular factors are required for virus proliferation. Here we discuss those cellular proteins known as molecular chaperones, which are essential for the assembly of functional viral DNA/RNA replicons. The function of these molecular chaperones in the cellular context is also discussed.

Foreword to ‘Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines’, a special issue in Honour of Fumio Arisaka’s 70th birthday

“…Of the articles fitting into this category, we have further sub-divided them into three sections (i) biomolecules and biophysical principles: in which we include contributions pitched at the level of molecular characterization or modelling based on basic physical principles (Soares da Costa et al 2018; Arai 2018a; Senda and Senda 2018;Kato et al 2018a;Arakawa 2018;Mizohata et al 2018;Mio and Sato 2018;North et al 2018;Unzai 2018;Furutani 2018;Rivas and Minton 2018;Akazawa-Ogawa et al 2018;Uchiyama et al 2018;Nagai et al 2018;Ando 2018;Sawitri et al 2018;Ogawa and Hirokawa 2018;Okamoto et al 2018;Fujiwara and Masuda 2018;Sahlan et al 2018;Takahashi et al 2018; Mitsutake and Takano 2018), (ii) molecular assemblies: where we include articles examining the mechanism of, and functional effects produced by, changes in biomolecular quaternary structure (Arai 2018b; Toda et al 2018;Yagi et al 2018;Kato et al 2018b;Kohda 2018;Urade et al 2018;Sekiya et al 2018 To each of the Guest Editors, Fumio has played a different role. To DH, he was a much appreciated supervisor (2007) and continuing academic collaborator (2008-present); to JT, he was a friend and trusted academic colleague whilst working together at Tokyo Institute of Technology (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998) (and continues to be an invaluable advisor regarding the theoretical and practical aspects of analytical ultracentrifugation), whilst to HN, he was a university colleague, fellow committee mem...…”