Assembled Fe3O4 nanoparticles on Zn Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity

Chai, Juanhua; Ma, Yingying; Guo, Tonglai; He, Ying; Wang, Guangshuo; Si, Fangfang; Geng, Jiahong; Qi, Xiongwei; Chang, Guoqing; Ren, Zhigang; Yu, Rongmin; Song, Liye; Liu, Dong

doi:10.1016/j.clay.2022.106630

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…A polymer-magnetic composite consisting of poly( N -vinyl-2-pyrrolidone) and Fe 3 O 4 iron oxide ring-shaped nanostructure carrying doxorubicin have shown good in vivo tumour inhibition under magnetic hyperthermia [ 41 , 54 ]. Moreover, Zn-Al layered double hydroxide (LDH) nanosheets doped with Fe 3 O 4 MNPs carrying doxorubicin were found to be effective against HepG2 cancer cell line, according to a recent study [ 49 , 62 ]. This material was found to be pH responsive, with more acidic conditions resulting in a larger doxorubicin release profile, thus allowing scope for chemically triggered drug release.…”

Section: Drug Deliverymentioning

confidence: 99%

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

et al. 2022

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The advancement of biomedicine in a socioeconomically sustainable manner while achieving efficient patient-care is imperative to the health and well-being of society. Magnetic systems consisting of iron based nanosized components have gained prominence among researchers in a multitude of biomedical applications. This review focuses on recent trends in the areas of diagnostic imaging and drug delivery that have benefited from iron-incorporated nanosystems, especially in cancer treatment, diagnosis and wound care applications. Discussion on imaging will emphasise on developments in MRI technology and hyperthermia based diagnosis, while advanced material synthesis and targeted, triggered transport will be the focus for drug delivery. Insights onto the challenges in transforming these technologies into day-to-day applications will also be explored with perceptions onto potential for patient-centred healthcare.

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Section: Drug Deliverymentioning

confidence: 99%

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

et al. 2022

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“…Magnetite nanoparticles (Fe 3 O 4 NPs) have risen to prominence in many applications that facilitate the rapid advancement of nanoscale-based high-technology. Fe 3 O 4 NPs have exhibited exceptional features, including ease of synthesis, small sizes, relative non-toxicity, superparamagnetic crystal, and strong magnetic properties [1] , [2] , and their potential as a promising candidate for a wide range of biomedical applications, such as targeted drug delivery, tumor detection and treatment, and magnetic resonance imaging (MRI) has been validated [3] , [4] , [5] . Despite extensive research on the exploration of Fe 3 O 4 NPs, poor optical properties, and weak electrical conductivity hinders their widespread implementation [6] .…”

Section: Introductionmentioning

confidence: 99%

Optimization of ultrasonic-assisted approach for synthesizing a highly stable biocompatible bismuth-coated iron oxide nanoparticles using a face-centered central composite design

Braim

Razak

Aziz

et al. 2023

Ultrasonics Sonochemistry

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“…At the same time, the nanosystem could be used as a highly effective photothermal therapy system [ 19 ]. The nanocostructure could consist of already known and partially characterized components: layered double hydroxide (LDH) nanoparticles, Fe 3 O 4 nanoparticles incorporated into the LDH structure, metal nanoparticles (i.e., Au, Pd, Pt, Ag) and complex compounds of these metals [ 20 , 21 , 22 ]. When the advantages of the individual components are combined, it is possible to obtain a product that would be effective in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Inorganic Nanomaterials Used in Anti-Cancer Therapies:Further Developments

et al. 2023

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In this article, we provide an overview of the progress of scientists working to improve the quality of life of cancer patients. Among the known methods, cancer treatment methods focusing on the synergistic action of nanoparticles and nanocomposites have been proposed and described. The application of composite systems will allow precise delivery of therapeutic agents to cancer cells without systemic toxicity. The nanosystems described could be used as a high-efficiency photothermal therapy system by exploiting the properties of the individual nanoparticle components, including their magnetic, photothermal, complex, and bioactive properties. By combining the advantages of the individual components, it is possible to obtain a product that would be effective in cancer treatment. The use of nanomaterials to produce both drug carriers and those active substances with a direct anti-cancer effect has been extensively discussed. In this section, attention is paid to metallic nanoparticles, metal oxides, magnetic nanoparticles, and others. The use of complex compounds in biomedicine is also described. A group of compounds showing significant potential in anti-cancer therapies are natural compounds, which have also been discussed.

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Assembled Fe3O4 nanoparticles on Zn Al LDH nanosheets as a biocompatible drug delivery vehicle for pH-responsive drug release and enhanced anticancer activity

Cited by 21 publications

References 31 publications

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

Iron-Based Magnetic Nanosystems for Diagnostic Imaging and Drug Delivery: Towards Transformative Biomedical Applications

Optimization of ultrasonic-assisted approach for synthesizing a highly stable biocompatible bismuth-coated iron oxide nanoparticles using a face-centered central composite design

Inorganic Nanomaterials Used in Anti-Cancer Therapies:Further Developments

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