Assaying for antiviral activity of the folkloric medicinal desert plant <i>Rhazya stricta</i> on coronavirus SARS-CoV-2

Baeshen, Mohammed N.; Attar, Roba; Bouback, Thamer A.; Albeshri, Abdulaziz; Baeshen, Naseebh N.; Karkashan, Alaa; Abbas, Basil A.; Aljaddawi, Abdullah A.; Almulaiky, Yaaser Q.; Mahmoud, Sara H.; Shama, Noura M. Abo; Ali, Mohamed A.; Baadhaim, Moayad; Zakri, Samer; Alsayegh, Khaled; Mohammed, Arif; Baeshen, Nabih A.

doi:10.1080/13102818.2022.2047107

Cited by 4 publications

(2 citation statements)

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“…Cell-based assays demonstrated a reduction in viral infection by ≥80% or ≥99%, while black chokeberry juice was found to be the most effective suppressor of SARS-CoV-2 with a percentage inhibition of 96% [41]. Baeshen et al (2022) explored the anti-SARS-CoV-2 activity of natural extracts of the desert medicinal plant Rhazya stricta in a dose-dependent way. The highest activity was observed for the nonalkaloidal fraction (IC 50 : 0.0461 mg/mL; CC 50 : 0.18 mg/mL), and then weak base alkaloids had activity with an IC 50 of 0.0474 mg/mL and a CC 50 of 0.0464 mg/mL [42].…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…Baeshen et al (2022) explored the anti-SARS-CoV-2 activity of natural extracts of the desert medicinal plant Rhazya stricta in a dose-dependent way. The highest activity was observed for the nonalkaloidal fraction (IC 50 : 0.0461 mg/mL; CC 50 : 0.18 mg/mL), and then weak base alkaloids had activity with an IC 50 of 0.0474 mg/mL and a CC 50 of 0.0464 mg/mL [42]. A natural nutraceutical, BEN815, contained extracts of green tea leaves (Camellia sinensis), guava leaves (Psidium guajava), and rose petals (Rosa hybrida) that displayed an antiviral effect against SARS-CoV-2 (IC 50 value = 34.38 µg/mL).…”

Section: In Vitro Studiesmentioning

confidence: 99%

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A Comprehensive Update of Various Attempts by Medicinal Chemists to Combat COVID-19 through Natural Products

et al. 2023

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The ongoing COVID-19 pandemic has resulted in a global panic because of its continual evolution and recurring spikes. This serious malignancy is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the outbreak, millions of people have been affected from December 2019 till now, which has led to a great surge in finding treatments. Despite trying to handle the pandemic with the repurposing of some drugs, such as chloroquine, hydroxychloroquine, remdesivir, lopinavir, ivermectin, etc., against COVID-19, the SARS-CoV-2 virus continues its out-of-control spread. There is a dire need to identify a new regimen of natural products to combat the deadly viral disease. This article deals with the literature reports to date of natural products showing inhibitory activity towards SARS-CoV-2 through different approaches, such as in vivo, in vitro, and in silico studies. Natural compounds targeting the proteins of SARS-CoV-2—the main protease (Mpro), papain-like protease (PLpro), spike proteins, RNA-dependent RNA polymerase (RdRp), endoribonuclease, exoribonuclease, helicase, nucleocapsid, methyltransferase, adeno diphosphate (ADP) phosphatase, other nonstructural proteins, and envelope proteins—were extracted mainly from plants, and some were isolated from bacteria, algae, fungi, and a few marine organisms.

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Section: In Vitro Studiesmentioning

confidence: 99%

Section: In Vitro Studiesmentioning

confidence: 99%