Assay of tipranavir capsules by a simple stability-indicating LC–UV method and cytotoxicity study of degraded samples

Somavilla, Leila P.; Lago, Matheus Wagner; Barth, Patricia Orlandi; Nogueira-Librelotto, Daniele Rubert; Rolim, Clarice Madalena Bueno; Adams, Andréa Inês Horn

doi:10.1007/s11696-019-00771-4

Cited by 1 publication

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antiviral medicines have been quantified using a variety of methods, including UV, capillary electrophoresis, and chromatographic methods such as GC and HPLC, LC-MS, and GC-MS. The authors of this review focus on stability, recommending HPLC/RP-HPLC technologies for the precise and effective development and validation of antiviral medicines such as Zidovudine, [15][16][17][18][19][20] Lamivudine, [20][21][22][23] Nevirapine, [24][25][26][27] Ritonavir, [28][29][30][31] Abacavir, [32][33][34] Efavirenz, [35][36][37][38] Tenofovir, [39][40][41] Fosamprenavir, [42][43][44][45][46] Atazanavir, [47][48] Emtricitabine, 35,35,39,49 Fosamprenavir, [42][43][44][45][46] Tipranavir, [50][51] Darunavir, [52]…”

Section: Various Stability Indicating Methodsmentioning

confidence: 99%

Overview of Forced Degradation Analysis for FDA Approved Antiretroviral agents: A Review

Lamichhane¹,

Das²,

Adhikari³

et al. 2022

J Young Pharm

View full text Add to dashboard Cite

Forced degradation and its analysis play a crucial role in the development and production of pharmaceutical products at various stages. Such studies include the assessment of appropriate drug candidates, product development, as well as comparability studies, clarification of probable intermediates and identification of by-products, and the development of stability-indicating technologies. The stability of drugs can be analyzed with Forced degradation study, which gives perspective knowledge of the molecule's stability as well as the degradant that is produced during the drug's shelf life. In this review on stability-indicating methods for FDA approved antiretroviral drugs from such as Zidovudine

show abstract