Assay of disopyramide in plasma by high-ressure liquid chromatography

Ilett, Kenneth F.; Hackett, L.P.; Dusci, L.J.; Tjokrosetio, Rose

doi:10.1016/s0021-9673(00)98489-9

Cited by 21 publications

(2 citation statements)

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“…[6][7][8][9][10] Therefore, our developed method is adequate for the pharmacokinetic studies and therapeutic drug monitoring, with possible simultaneous determination of DP and its main metabolite, mono-Ndesalkylated disopyramide in serum.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, enzyme immunoassay 5 , fluorescence polarization immunoassay (FPIA) 6 and high-performance liquid chromatography (HPLC) with UV detector [6][7][8][9][10] are used for the determination of DP in biological fluids. Immunoassay commercial kits are suitable to measure many samples, but not so fitting for testing DP metabolites owing to its cross reactivity.…”

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confidence: 99%

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High-Performance Liquid Chromatography with Chemiluminescence Detection of Disopyramide in Human Serum

1998

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Disopyramide (DP) [4-diisopropylamino-2-phenyl-2-(2-pyridyl)butyramide] is a widely used antiarrhythmic drug with class Ia activity, according to the Vaughan and Williams classification.1,2 It has pharmacological effects on the heart that are qualitatively similar to those of quinidine and procainamide.3 Because of a relative narrow therapeutic range (2 -5 µg ml -1 ) in serum or plasma, the monitoring of DP in blood is essential.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%