Assay of Antinuclear Antibodies by ELISA Using Nuclei as Antigen

Ara, Jahan; Ali, Rashid

doi:10.1515/cclm.1993.31.5.289

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANA (Adaltis Italia kit, Italia) 14 and anti-ds DNA (Bio-Rad Laboratories Diagnostic group kit, USA) 15 were assayed by enzyme linked immunosorbant technique. Serum C3 (Binding Site Ltd kit, UK) was determined by radial immunodiffusion.…”

Section: Tgf-␤ ␤1 Immunoassaymentioning

confidence: 99%

Transforming growth factor beta 1 in children with systemic lupus erythematosus: a possible relation with clinical presentation of lupus nephritis

Hammad

Youssef

El-Arman

2006

Lupus

View full text Add to dashboard Cite

Plasma and urinary (latent and active) TGF-beta1 levels were assessed in 32 children with active lupus and compared to 15 healthy controls of matched age and sex. Plasma latent and active TGF-beta1 levels in children with active disease were significantly lower than controls (P = 0.004 and P < 0.001 respectively). Plasma active TGF-beta1 correlated negatively with Systemic Lupus Erythematosus Disease Activity Index (r = -0.38, P = 0.03). On the contrary, urinary latent and active TGF-beta1 levels in children with active disease were significantly higher than controls (P < 0.001 and P = 0.003 respectively). Urinary active TGF-beta1 levels correlated positively with Anti-ds DNA titre (r = 0.42, P = 0.015) and negatively with serum C3 levels (r = -0.48, P = 0.005). Patients with symptomatic nephritis had significantly elevated urinary active TGF-beta1 levels in comparison to those with silent nephritis (P = 0.008). From this data we conclude that lowered plasma TGF-beta1 levels may be a feature of systemic immune dysfunction in children with active lupus while increased renal production of active TGF-beta1 seems to have a role in the clinical presentation of lupus nephritis.

show abstract

Section: Tgf-␤ ␤1 Immunoassaymentioning

confidence: 99%