Assay of amoxicillin sustained release from matrix tablets containing different proportions of Carbopol 971P NF

Tapia-Albarran, Manuel; Villafuerte-Robles, Leopoldo

doi:10.1016/j.ijpharm.2003.12.019

Cited by 29 publications

(16 citation statements)

References 16 publications

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“…Matrices can be prepared via direct compression or a wet granulation process (2)(3)(4)(5)(6)(7). Materials generally used in forming matrices are polymers, which can be organized into hydrophobic and hydrophilic groups.…”

Section: Introductionmentioning

confidence: 99%

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Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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Abstract. This work was aimed at evaluating the effect of a pharmaceutical cationic exchange resin (Amberlite IRP-69) on the properties of controlled release matrices using Methocel K4M (HPMC) or Ethocel 7cP (EC) as matrix formers. Diphenhydramine hydrochloride (DPH), which was cationic and water soluble, was chosen as a model drug. HPMC-and EC-based matrices with varying amounts (0-40%w/w) of resin incorporation were prepared by a direct compression. Matrix properties including diameter, thickness, hardness, friability, surface morphology and drug release were evaluated. The obtained matrices were comparable in diameter and thickness regardless of the amount of resin incorporation. Increasing the incorporated resin decreased the hardness of HPMC-and EC-based matrices, correlating with the degree of rupturing on the matrix surfaces. The friability of HPMC-based matrices increased with increasing the incorporated resin, corresponding to their decreased hardness. In contrast, the EC-based matrices showed no significant change in friability in spite of decreasing hardness. The incorporated resin differently influenced DPH release from HPMC-and EC-based matrices in deionized water. The resin further retarded DPH release from HPMC-based matrices due to the gelling property of HPMC and the ion exchange property of the resin. In contrast, the release from EC-based matrices initially increased because of the disintegrating property of the resin, but thereafter declined due to the complex formation between released drug and dispersed resin via the ion exchange process. The release in ionic solutions was also described. In conclusion, the incorporated resin could alter the release and physical properties of matrices.

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Section: Introductionmentioning

confidence: 99%

“…Polymers selected from either the same or different groups can be admixed to modify the rate and mechanism of drug release from matrices (2,3). In addition, drug release from matrices may be tuned by adjustment of polymer concentration or/and addition of other excipients (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

et al. 2008

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“…Therefore, it is required to establish a simple, selective, and sensitive method for analysis as well as specific dissolution conditions to overcome the errors in the release data. This study proposed a simple dissolution method capable of discriminating between different AmoxT gastroretentive formulations without any additional experimental or calculation steps, such as correction for degradation product (18) and the variation of degradation kinetics (33), which allow for additional experimental errors. Furthermore, the UV method could be applied as a simpler and lower cost method than the time-consuming and more expensive HPLC method.…”

Section: Resultsmentioning

confidence: 99%

“…For gastric ulcer patients, amoxicillin is ineffective even at high doses, apparently due to limited contact time with the target site when administered in a conventional oral dosage form (16). The failure of amoxicillin has been proposed to be an outcome of subtherapeutic bactericidal concentrations available at the site and instability of amoxicillin following oral administration (17,18). H. pylori live deep within the gastric mucus layer, and prolonged local application of drug is needed for its sufficient diffusion to the bacteria.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

Emara¹,

Abdou²,

El-Ashmawy³

et al. 2013

Dissolution Technol.

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Floating amoxicillin trihydrate (AmoxT) tablets, used for eradication of Helicobacter pylori (H. pylori), were prepared according to a gas-generating technique to extend the drug residence time in the stomach. The drug release rate from the floating tablets in acidic dissolution medium, in which AmoxT is known to be unstable, was studied using two dissolution techniques: openloop system of the flow-through cell (FTC) and the beaker method. Analysis of AmoxT in the dissolution medium was carried out by UV spectrophotometric and HPLC methods. The comparison indicates that the open-loop system of the FTC, which is based on non-cumulative (fresh) dissolution samples, is the preferred dissolution technique, and in this case, the drug could be analyzed by UV spectrophotometric and HPLC methods. However, in the case of a large number of QC samples, UV spectrophotometry is preferred to the HPLC method, which requires relatively longer time for analysis thereby increasing drug degradation. On the other hand, in the case of the beaker method, which is based on cumulative dissolution samples, the drug must be analyzed by HPLC. Generally, the beaker method is not recommended due to the problems associated with the accumulation of AmoxT degradation product in the dissolution medium. This study describes a simple dissolution method capable of discriminating between different AmoxT gastroretentive formulations without any additional experimental or calculational steps.

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“…However, in some cases where the drug is acid labile, the degradation might be fast enough so that the resultant degradation products interfere with the simple nonselective UV procedure (15). Such a potentially serious effect on the overall dissolution results has been demonstrated for amoxicillin capsules (16). Concerning dissolution testing of LPZ; the USP (1) adopts a UV spectroscopic method while the BP (2) adopts a more selective HPLC method.…”

Section: Ansoprazole (Lpz Shown Inmentioning

confidence: 99%

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

Hammad¹,

Hamdan²,

El-Sabawi³

2016

Dissolution Technol.

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The performance of the analytical methodologies recommended by the United States Pharmacopoeia (USP) monograph (1) for dissolution testing of lansoprazole (LPZ) enteric-coated solid dosage forms (capsules/tablets) was critically evaluated. While USP adopts an essentially nonselective UV method, the British Pharmacopoeia (2) recommends a highperformance liquid chromatography (HPLC) method capable of separating the drug from its acid degradation products. For an acid-labile drug such as LPZ, one might think that the nonselective UV method might over-or underestimate the percentage released because the degradation product might have UV absorptivity different from that of the parent drug. We subjected six commercial products in addition to the reference product (G) to analysis according to the USP assay and dissolution recommendations. Products were also subjected to dissolution tests whereby a selective HPLC method was employed for quantifying the percentage release. All products passed USP assay tests. For dissolution, the UV method adopted by USP was more reliable because it indicated the actual percentage released compared with the selective HPLC method, which reflected only the percentage of released LPZ that remained intact (undegraded). Only one product (E) failed to satisfy the USP requirements for dissolution.

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Assay of amoxicillin sustained release from matrix tablets containing different proportions of Carbopol 971P NF

Cited by 29 publications

References 16 publications

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers

In Vitro Release Evaluation of Gastroretentive Amoxicillin Floating Tablets Employing a Specific Design of the Flow-Through Cell

Assessment of the Pharmacopeial Analytical Methodologies in the Dissolution Test of Enteric-Coated Lansoprazole Preparations

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