Adipose tissue secretes the hormone asprosin. The asprosin molecule has several roles in the central nervous system and other body systems: hunger, glucose metabolism, insulin resistance (IR), and cellular death. IR is pathologically associated with high asprosin levels. Patients with type 2 diabetes mellitus (DMІІ) are more likely to have thyroid problems. Over time, many diabetics develop thyroid dysfunctional symptoms. The study included 80 women. Forty had hypothyroidism with diabetes (DMII), and 40 were healthy controls. Gathered samples from the National Diabetes Center,