Asprosin in pregnancy and childhood

Janoschek, Ruth; Hoffmann, Thorben; Morcos, Yousef Ashraf Tawfik; Sengle, Gerhard; Dötsch, Jörg; Hucklenbruch‐Rother, Eva

doi:10.1186/s40348-020-00110-8

Cited by 14 publications

(15 citation statements)

References 25 publications

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“…Currently, the function of asprosin glycosylation is not clear, however, similar to other proteins it is possible that it keeps asprosin more soluble and may therefore prevent its aggregation in blood 29 . By employing our newly raised polyclonal asprosin antibody we established sensitive direct and sandwich ELISAs with a reliable detection below 0.15 ng/ml which is comparable to the stated sensitivity of commercially available ELISA kits used in previous studies 5 (Supplementary Table S1 ). The high affinity of the generated pc-asp (K D ~ 300 pM) also enabled us to selectively concentrate asprosin from complex clinical samples via antibody affinity chromatography.…”

Section: Discussionmentioning

confidence: 61%

Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin

Morcos

Lütke

Tenbieg

et al. 2022

Sci Rep

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The C-terminal pro-fibrillin-1 propeptide asprosin is described as white adipose tissue derived hormone that stimulates rapid hepatic glucose release and activates hunger-promoting hypothalamic neurons. Numerous studies proposed correlations of asprosin levels with clinical parameters. However, the enormous variability of reported serum and plasma asprosin levels illustrates the need for sensitive and reliable detection methods in clinical samples. Here we report on newly developed biochemical methods for asprosin concentration and detection in several body fluids including serum, plasma, saliva, breast milk, and urine. Since we found that glycosylation impacts human asprosin detection we analyzed its glycosylation profile. Employing a new sandwich ELISA revealed that serum and saliva asprosin correlate strongly, depend on biological sex, and feeding status. To investigate the contribution of connective tissue-derived asprosin to serum levels we screened two cohorts with described cartilage turnover. Serum asprosin correlated with COMP, a marker for cartilage degradation upon running exercise and after total hip replacement surgery. This together with our finding that asprosin is produced by primary human chondrocytes and expressed in human cartilage suggests a contribution of cartilage to serum asprosin. Furthermore, we determined asprosin levels in breast milk, and urine, for the first time, and propose saliva asprosin as an accessible clinical marker for future studies.

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Section: Discussionmentioning

confidence: 61%

Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin

Morcos

Lütke

Tenbieg

et al. 2022

Sci Rep

Self Cite

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“…The level of asprosin has been reported to be increased in obese children with higher levels in the female gender compared to males (6)(7)(8).…”

Section: Asprosin In Obese Childrenmentioning

confidence: 99%

“…In addition, the plasma levels of asprosin in pregnant women diagnosed with GDM are associated with the plasma levels of asprosin in their neonates. The level of asprosin has been reported to be higher in female neonates compared to males Asprosin has also been reported to be expressed in the placenta (4)(5)(6).…”

Section: Asprosin In Pregnant Women and Their Newbornsmentioning

confidence: 99%

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Asprosin; effects and associations

Hassanzadeh¹,

Nasri

2021

J Prev Epidemiol

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Asprosin is a hormone that is released by the white adipose tissue. It stimulates the release of glucose, which is produced in the liver, into the blood. Asprosin targets many organs including the skeletal muscle, pancreas, liver, and cardiac system. In addition, asprosin stimulates appetite leading to weight gain. It also influences glucose metabolism, cell apoptosis, and insulin resistance. Furthermore, it has been implicated in some medical conditions such as obesity and diabetes.

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“…The prevalence of overweight and obesity during pregnancy has steadily increased in recent decades and can lead to complications and disorders for mother and child (Janoschek et al, 2020). Weight gain greater than recommended is defined as excessive gestational weight gain (EGWG) (Barton et al, 2015; Hutcheon et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Association of maternal and umbilical cord blood asprosin with excessive gestational weight gain

et al. 2022

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Maternal obesity and excessive gestational weight gain (EGWG) may have persistent effects on offspring obesity and be risk factors for both mother and child. Studies have reported that asprosin concentration is associated with metabolism and weight changes during pregnancy. This study therefore evaluated the association of maternal and newborn asprosin with normal weight gain and EGWG and nutritional intake in pregnancy. The study included 30 pregnant women with normal weight gain and 30 women with EGWG referred to Ali ibn Abi Talib Hospital in Zahedan, Iran, September 2020 to June 2021. A demographic questionnaire and neonatal complications checklist were completed. Asprosin concentrations at the time of delivery in maternal venous blood samples and umbilical vein blood samples were measured by ELISA technique. Macronutrient and energy intake were assessed by a 24-h dietary recall questionnaire and compared with standard Recommended Dietary Allowance (RDA) and Dietary References Intake (DRI) values. Asprosin levels were significantly higher in the EGWG group's umbilical cord blood than in the control group but there was no difference in maternal asprosin concentrations between the two groups. The Appearance, Pulse, Grimace, Activity and Respiration (Apgar) score was significantly lower in the EGWG group than in the control group, although there was no difference in birthweight between the groups. Weight gain during pregnancy, energy intake and protein and carbohydrate consumption were significantly higher in the EGWG group than in the control group (p < 0.05). It seems that differences in asprosin secretion do not mediate an imbalance in energy intake and other macronutrients during pregnancy that affect pregnancy weight gain and birthweight. However, excessive gestational weight gain was associated with neonatal asprosin levels and newborn Apgar scores.

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Asprosin in pregnancy and childhood

Cited by 14 publications

References 25 publications

Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin

Sensitive asprosin detection in clinical samples reveals serum/saliva correlation and indicates cartilage as source for serum asprosin

Asprosin; effects and associations

Association of maternal and umbilical cord blood asprosin with excessive gestational weight gain

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