ASPORIN: A root of the matter in tumors and their host environment

Lall, Shobhit P.; Alsafwani, Zahraa W.; Batra, Surinder K.; Seshacharyulu, Parthasarathy

doi:10.1016/j.bbcan.2023.189029

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

2024

DOI: 10.1016/j.bbcan.2023.189029

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ASPORIN: A root of the matter in tumors and their host environment

Shobhit P. Lall,

Zahraa W. Alsafwani,

Surinder K. Batra

et al.

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2024

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CD44 and its implication in neoplastic diseases

Xu,

Bai,

Lan

et al. 2024

MedComm

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CD44, a nonkinase single span transmembrane glycoprotein, is a major cell surface receptor for many other extracellular matrix components as well as classic markers of cancer stem cells and immune cells. Through alternative splicing of CD44 gene, CD44 is divided into two isoforms, the standard isoform of CD44 (CD44s) and the variant isoform of CD44 (CD44v). Different isoforms of CD44 participate in regulating various signaling pathways, modulating cancer proliferation, invasion, metastasis, and drug resistance, with its aberrant expression and dysregulation contributing to tumor initiation and progression. However, CD44s and CD44v play overlapping or contradictory roles in tumor initiation and progression, which is not fully understood. Herein, we discuss the present understanding of the functional and structural roles of CD44 in the pathogenic mechanism of multiple cancers. The regulation functions of CD44 in cancers‐associated signaling pathways is summarized. Moreover, we provide an overview of the anticancer therapeutic strategies that targeting CD44 and preclinical and clinical trials evaluating the pharmacokinetics, efficacy, and drug‐related toxicity about CD44‐targeted therapies. This review provides up‐to‐date information about the roles of CD44 in neoplastic diseases, which may open new perspectives in the field of cancer treatment through targeting CD44.

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CD44 and its implication in neoplastic diseases

Xu,

Bai,

Lan

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

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ASPORIN: A root of the matter in tumors and their host environment

Cited by 1 publication

References 161 publications

CD44 and its implication in neoplastic diseases

CD44 and its implication in neoplastic diseases

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