Aspirin vs Heparin for the Prevention of Preeclampsia

Katsi, Vasiliki; Kanellopoulou, Theoni; Makris, Thomas; Nihoyannopoulos, Petros; Nomikou, E.; Tousoulis, Dimitrios

doi:10.1007/s11906-016-0664-3

Cited by 14 publications

(14 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Independently of the obvious heparin anticoagulant effect, there is now considerable evidence that heparin possesses antiinflammatory, anti-apoptotic and proliferative activities that rely on a variety of mechanisms (Katsi et al, 2016). However, the polyanionic nature of heparin favours the neutralization of cationic mediators of inflammation and apoptosis but, also viral envelopes (Rusnati et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

et al. 2017

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

et al. 2017

View full text Add to dashboard Cite

“…Heparin could be an alternative antithrombotic and anti-inflammatory median to prevent PE, especially associated to thrombophilia [78]; however, evidence on the efficacy is conflicting. To date, there is no definite evidence that antithrombotic drugs are effective for prevention of recurrence of gestational vascular complications, especially PE [79,102,103]. LMWH may have other positive impacts on the placental vascular system [103].…”

Section: Metforminmentioning

confidence: 99%

Can Endothelial Glycocalyx Be A Major Morphological Substrate in Pre-Eclampsia?

Ziganshina

Yarotskaya

Bovin

et al. 2020

IJMS

View full text Add to dashboard Cite

Today pre-eclampsia (PE) is considered as a disease of various theories; still all of them agree that endothelial dysfunction is the leading pathogenic factor. Endothelial dysfunction is a sequence of permanent immune activation, resulting in the change of both the phenotype and the functions of an endothelial cell and of the extracellular layer associated with the cell membrane—endothelial glycocalyx (eGC). Numerous studies demonstrate that eGC mediates and regulates the key functions of endothelial cells including regulation of vascular tone and thromboresistance; and these functions are disrupted during PE. Taking into account that eGC and its components undergo alterations under pathological conditions leading to endothelial activation, it is supposed that eGC plays a certain role in pathogenesis of PE. Envisaging the eGC damage as a key factor of PE, might be a new approach to prevention, treatment, and rehabilitation of patients with PE. This approach could include the development of drugs protecting eGC and promoting regeneration of this structure. Since the issue of PE is far from being solved, any effort in this direction might be valuable.

show abstract

“…27 More recent studies have examined the effect of prophylactic anticoagulation in addition to aspirin on placenta-mediated complications with conflicting results. 28–30 The evidence regarding the dose-dependent efficacy and impact of gestational age at initiation are similarly poorly defined. 31, 32 …”

Section: Commentmentioning

confidence: 99%

Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Tolcher

Chu

Hollier

et al. 2017

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

BACKGROUND The U.S. Preventive Services Task Force (USPSTF) recommends low-dose aspirin for the prevention of preeclampsia among women at high risk for primary occurrence or recurrence of disease. Recommendations for the use of aspirin for preeclampsia prevention were issued by the USPSTF in September 2014. OBJECTIVES To evaluate the incidence of recurrent preeclampsia in our cohort before and after the USPSTF recommendation for aspirin for preeclampsia prevention. STUDY DESIGN This is a retrospective cohort study designed to evaluate rates of recurrent preeclampsia among women with a history of preeclampsia. We utilized a two hospital, single academic institution database from August 2011 through June 2016. We excluded multiple gestations and included only the first delivery for women with multiple deliveries during the study period. The cohort of women with a history of preeclampsia were divided into two groups, “before” and “after” the release of the USPSTF 2014 recommendations. Potential confounders were accounted for in multivariate analyses, and relative risk and adjusted relative risk were calculated. RESULTS 17,256 deliveries occurred during the study period. A total of 417 women had a documented history of prior preeclampsia; 284 women “before” and 133 women “after” the USPSTF recommendation. Comparing the before and after groups, the proportion of Hispanic women in the after group was lower and the method of payment differed between the groups (P <.0001). The prevalence of type 1 diabetes was increased in the after period, but overall rates of pregestational diabetes were similar (6.3% before versus 5.3% after; P >.05). Risk factors for recurrent preeclampsia included maternal age >35 years (RR, 1.83; 95% CI, 1.34–2.48), Medicaid insurance (RR, 2.08; 95% CI, 1.15–3.78), type 1 diabetes (RR, 2.13; 95% CI, 1.37–3.33), and chronic hypertension (RR, 1.96; 95% CI, 1.44–2.66). The risk of recurrent preeclampsia was decreased by 30% in the after group (adjusted relative risk (aRR), 0.70; 95% CI, 0.52- 0.95). CONCLUSION Rates of recurrent preeclampsia among women with a history of preeclampsia decreased by 30% after release of the USPSTF recommendation for aspirin for preeclampsia prevention. Future prospective studies should include direct measures of aspirin compliance, gestational age at initiation, and explore the influence of race and ethnicity on the efficacy of this primary prevention.

show abstract

Aspirin vs Heparin for the Prevention of Preeclampsia

Cited by 14 publications

References 57 publications

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Can Endothelial Glycocalyx Be A Major Morphological Substrate in Pre-Eclampsia?

Impact of USPSTF recommendations for aspirin for prevention of recurrent preeclampsia

Contact Info

Product

Resources

About