Aspirin‐triggered 15‐HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin‐Sensitive Patients Identification Test (ASPITest)*

Kowalski, Marek L.; Ptasińska, Anetta; Jędrzejczak, Marta; Bieńkiewicz, Barbara; Cieślak, M; Grzegorczyk, Janina; Pawliczak, Rafał; DuBuske, L.M.

doi:10.1111/j.1398-9995.2005.00836.x

Cited by 83 publications

(54 citation statements)

References 37 publications

(38 reference statements)

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“…In Europe and Asia, the lysine-aspirin bronchoprovocation test is widely used, but these provocation tests are time-consuming and could produce severe asthmatic reactions, putting both patients and doctors at risk. Several studies have attempted to develop an in vitro diagnostic test for AIA, and it was reported that the level of aspirin-induced 15-hydroxyeicosatetranoic acid (15-HETE) in peripheral blood might be a specific in vitro test for identifying aspirin-sensitive patients (ASPI test); however, the test lacks sensitivity and requires complicated procedures, and the methodology has not been well standardized [28]. Although we need further validation studies in other populations, this SNP set based on a multilocus genetic interaction could be used as an in vitro test for predicting the risk of AIA.…”

Section: Discussionmentioning

confidence: 99%

Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics

et al. 2008

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Introduction Aspirin-intolerant asthma (AIA), a major clinical presentation of aspirin hypersensitivity, affects 10% of adult asthmatics. The genetic risk factors involved in the susceptibility to AIA have recently been investigated, but multilocus single-nucleotide polymorphisms (SNPs) associated with this susceptibility has not been evaluated. Methods We examined 246 asthmatic patients: 94 having aspirin intolerance and 152 having aspirin tolerance. We selected 23 SNPs of 13 candidate genes and genotyped each SNP using a primer extension method. Multilocus genetic interactions were examined using multifactor dimensionality reduction (MDR) to test all multilocus SNP combinations to identify a useful SNP set for predicting the AIA phenotype. Results We identified the best model using the MDR method, which consisted of a four-locus gene-gene interaction with 65.16% balanced accuracy and a cross-validation consistency of 70% in predicting AIA disease risk among asthmatic patients. This model included four SNPs such as B2ADR 46A>G, CCR3-520T>G, CysLTR1-634C>T, and FCER1B-109T>C.Discussion These results suggest that a multilocus SNP acts in combination to influence the susceptibility to aspirin intolerance in asthmatics and could be a useful genetic marker for the diagnosis of AIA.

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Section: Discussionmentioning

confidence: 99%

Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics

et al. 2008

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“…In about 10% of adult patients with asthma, aspirin and other NSAIDs that inhibit cyclooxygenase (COX) enzymes (COX-1 and COX-2) precipitate asthma attacks and naso-ocular reactions (148). This distinct clinical syndrome, called aspirin-induced asthma, is characterized by a typical sequence of symptoms: an intense eosinophilic inflammation of the nasal and bronchial tissues combined with an overproduction of cysteinyl leukotrienes (CysLT; 149) and other prostanoids (150,151). After the ingestion of aspirin or other NSAIDs, an acute asthma attack occurs within 3 hours, usually accompanied by profuse rhinorrhoea, conjunctival injection, periorbital edema and sometimes a scarlet flushing of the head and neck.…”

Section: Drug-induced Rhinitismentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

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3,749

1,755

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“…Based on this observation, measurement of 15-HETE release from PBL has been proposed as Aspirin Sensitive Patient Identification Test (ASPITest Ò ) (38). Clinical usefulness of this test has not yet been confirmed by larger studies.…”

Section: -Hete Generation Assay (Aspitest)mentioning

confidence: 99%

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA# and GA2LEN/HANNA*

Kowalski

Makowska

Blanca³

et al. 2011

Allergy

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382

356

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Following the first description of hypersensitivity reaction to aspirin (ASA) by Hirschberg in 1902, several types of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) have been described. The NSAIDs-induced hypersensitivity reactions involve different mechanisms and present a wide range of clinical manifestations from anaphylaxis AbstractNonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 21-25% of reported adverse drug events which include immunological and nonimmunological hypersensitivity reactions. This study presents up-to-date information on pathomechanisms, clinical spectrum, diagnostic tools and management of hypersensitivity reactions to NSAIDs. Clinically, NSAID hypersensitivity is particularly manifested by bronchial asthma, rhinosinusitis, anaphylaxis or urticaria and variety of late cutaneous and organ-specific reactions. Diagnosis of hypersensitivity to a NSAID includes understanding of the underlying mechanism and is necessary for prevention and management. A stepwise approach to the diagnosis of hypersensitivity to NSAIDs is proposed, including clinical history, in vitro testing and/ or provocation test with a culprit or alternative drug depending on the type of the reaction. The diagnostic process should result in providing the patient with written information both on forbidden and on alternative drugs.

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Aspirin‐triggered 15‐HETE generation in peripheral blood leukocytes is a specific and sensitive Aspirin‐Sensitive Patients Identification Test (ASPITest)*

Abstract: Our data demonstrate that ASA-induced 15-HETE generation by PBL is a specific and sensitive aspirin-sensitive patients identification test (ASPITest).

Cited by 83 publications

References 37 publications

Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics

Association of Four-locus Gene Interaction with Aspirin-intolerant Asthma in Korean Asthmatics

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA# and GA2LEN/HANNA*

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