Aspirin Treatment Is Associated With a Significantly Decreased Risk of Staphylococcus aureus Bacteremia in Hemodialysis Patients With Tunneled Catheters

Sedlacek, Martin; Gemery, John M.; Cheung, Ambrose L.; Bayer, Arnold S.; Remillard, Brian D.

doi:10.1053/j.ajkd.2006.12.014

Cited by 66 publications

(59 citation statements)

References 20 publications

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“…Age was not associated with higher risk for bacteremia in some studies (13)(14)(15)(16), whereas other studies reported higher risk of hospitalized septicemia in older patients (17). Although we assessed age as a binary predictor with a cutoff$75 years, previous studies used lower age cutoffs of $57 (15), $60 (14), or $65 years (17).…”

Section: Discussionmentioning

confidence: 98%

Risk of Catheter-Related Bloodstream Infection in Elderly Patients on Hemodialysis

Murea¹,

James²,

Russell³

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Elderly patients require tunneled central vein dialysis catheters more often than younger patients. Little is known about the risk of catheter-related bloodstream infection in this population. Results In total, 374 nonelderly and 90 elderly patients with mean (SD) ages of 54.8 (12.3) and 81.3 (4.9) years and dialysis vintages of 1.8 (3.3) and 1.5 (2.9) years (P=0.47), respectively, were identified. Mean at-risk catheter-days were 272 (243) in nonelderly and 318 (240) in elderly patients. Between age groups, there were no significant differences in initial catheter site, type of catheter lock solution, or microbiology results. A total of 208 catheterrelated bloodstream infection events occurred (190 events in nonelderly and 18 events in elderly patients), with a catheter-related bloodstream infection incidence per 1000 catheter-days of 1.97 (4.6) in nonelderly and 0.55 (1.6) in elderly patients (P,0.001). Relative to nonelderly patients, the hazard ratio for catheter-related bloodstream infection in the elderly was 0.33 (95% confidence interval, 0.20 to 0.55; P,0.001) after multivariate analysis.Conclusion Elderly patients on hemodialysis using tunneled central vein dialysis catheters are at lower risk of catheter-related bloodstream infection than their younger counterparts. For some elderly patients, tunneled central vein dialysis catheters may represent a suitable dialysis access option in the setting of nonmaturing arteriovenous fistulae or poorly functioning synthetic grafts.

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Section: Discussionmentioning

confidence: 98%

Risk of Catheter-Related Bloodstream Infection in Elderly Patients on Hemodialysis

Murea¹,

James²,

Russell³

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Clinically, aspirin treatment was associated with a significant decrease in risk of Staphylococcus aureus bacteraemia (Sedlacek et al 2007). Aspirin was recommended to be given postoperatively to decrease graft infections emerging due to coagulase-negative staphylococcus owing to its antiadhesion properties (Demirag et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The assessment of the antibacterial and antifungal activities of aspirin, EDTA and aspirin-EDTA combination and their effectiveness as antibiofilm agents

Al‐Bakri

Othman

Bustanji

2009

Journal of Applied Microbiology

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Aims: To evaluate the antimicrobial activities of aspirin, EDTA and an aspirin‐EDTA (A‐EDTA) combination against Pseudomonas aeruginosa, Escherichia coli and Candida albicans in planktonic and biofilm cultures. Methods and Results: Minimal inhibitory concentrations (MIC) and minimal biocidal concentrations (MBC) were determined using twofold broth microdilution and viable counting methods, respectively. Aspirin’s recorded MIC values ranged from 1·2 to 2·7 mg ml−1. Checkerboard assay demonstrated a synergism in antimicrobial activity upon combination. Aspirin’s minimal biofilm eradication concentration values (MBEC) against the established biofilms ranged between 1·35 and 3·83 mg ml−1. A complete eradication of bacterial biofilms was achieved after a 4‐h treatment with the A‐EDTA combination. Conclusion: Both aspirin and EDTA possess broad‐spectrum antimicrobial activity for both planktonic and biofilm cultures. Aspirin used at the MBEC for 24 h was successful in eradicating P. aeruginosa, E. coli and C. albicans biofilms established on abiotic surfaces. Moreover, the exposure to the A‐EDTA combination (4 h) effected complete bacterial biofilm eradication. Significance and Impact of the Study: There is a continuous need for the discovery of new antimicrobial agents. Aspirin and EDTA are ‘nonantibiotic drugs’, the combination of which can be used successfully to treat and eradicate biofilms established on abiotic surfaces.

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“…8,9 Pacemaker lead loops were defined as the pres ence of excessively elongated leads in the atrium or in the ventricle protruding into the tricuspid valve orifice (FIGURE 1B and 1C). 10 Intracardiac lead abrasion (ILA) was diagnosed if damage to the outer lead insulation in the in tracardiac segment (15)(16)(17)(18)(19)(20) cm from the lead tip) was detected during visual inspection (FIGURE 1D and 1E). 10 Data analysis Potential risk factors for infec tious complications were analyzed in patients with CIED infections, who were divided into 2 main groups: with PI and with LRIE, and were further subdivided into those with IPI, ILRIE, and LRIE + PI, as compared with patients with non infectious complications.…”

Section: Procedures -Related Factorsmentioning

confidence: 99%

Infectious complications in patients with cardiac implantable electronic devices – risk factors, prevention and prognosis

Polewczyk¹,

Jacheć²,

Polewczyk³

et al. 2017

Polish Archives of Internal Medicine

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597has been rising due to an increasing number of ICD or CRT device implantations in a specif ic population of patients with severe heart fail ure (HF) and comorbidities. Furthermore, re cent years have witnessed a tremendous increase in average life expectancy, which translates into a higher number of reinterventions (generator re placement, system upgrade) in patients receiving CIEDs. 2-6 A significant increase in the incidence INTRODUCTION Cardiac implantable electron ic device (CIED) infections, which develop in pa tients with pacemakers, implantable cardiovert er-defibrillators (ICDs), and cardiac resynchro nization therapy (CRT) devices, pose a major clinical challenge. The incidence of these infec tions is estimated to range from 1% to 2% in pa tients with CIEDs.1 However, these data are inac curate because the incidence of CIED infections OBJECTIVES The aim of this study was to assess the risk factors and long term survival of patients with CIED infections. PATIENTS AND METHODSWe analyzed the clinical data of 1837 patients (including xx [40.9%] patients with CIED infections), who underwent transvenous lead extraction at a single institution between 2006 and 2015. We compared the clinical and procedure related factors for all types of CIED infections: iso lated pocket infection (IPI), isolated lead related infective endocarditis (ILRIE), and lead related infective endocarditis with coexisting pocket infection (LRIE + PI). We also analyzed long term survival rates. RESULTSThe development of IPI and LRIE + PI depended mainly on age, male sex, number of leads, presence of implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT D), and the number of previous procedures. The factors that determined ILRIE included chronic renal failure (CRF), ICD/CRT D, lead loops, and intracardiac lead abrasion. Chronic anticoagulation and antiplatelet treatment protected against the development of infection. Long term survival was significantly related to age, heart failure, diabetes mellitus, CRF, malignancy, and chronic atrial fibrillation.CONCLUSIONS The development of all types of CIED infection was associated mainly with procedure related factors, while long term mortality was dependent on clinical factors. The dissimilarity of factors affecting the development of IPI and ILRIE confirms that there are 2 variants of CIED infection. The pro tective effects of chronic anticoagulation and antiplatelet treatment should prompt us to consider such therapy in the prevention of CIED infection.

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Aspirin Treatment Is Associated With a Significantly Decreased Risk of Staphylococcus aureus Bacteremia in Hemodialysis Patients With Tunneled Catheters

Cited by 66 publications

References 20 publications

Risk of Catheter-Related Bloodstream Infection in Elderly Patients on Hemodialysis

Risk of Catheter-Related Bloodstream Infection in Elderly Patients on Hemodialysis

The assessment of the antibacterial and antifungal activities of aspirin, EDTA and aspirin-EDTA combination and their effectiveness as antibiofilm agents

Infectious complications in patients with cardiac implantable electronic devices – risk factors, prevention and prognosis

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