Aspirin-Stimulated Nitric Oxide Production by Neutrophils After Acute Myocardial Ischemia in Rabbits

Lo´pez-Farre´, A.; Riesco, Amparo; Digiuni, Enzo; Mosquera, Juan R.; Caramelo, Carlos; Miguel, Lourdes Sánchez de; ́s, Inmaculada Milla; Frutos, Trinidad de; Cernadas, M R; ́n, Mercedes Monto; Alonso, Javier; Casado, Santos

doi:10.1161/01.cir.94.1.83

Cited by 45 publications

(22 citation statements)

References 28 publications

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“…Generally, NO can induce cell death by apoptosis in a variety of different cell types (López-Farré et al, 1996;Messmer et al, 1996). There are various biochemical and cellular mechanisms underlying NO-induced apoptosis, e.g.…”

Section: Discussionmentioning

confidence: 99%

The effects of l-arginine and l-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue

Petrović

Korać

Buzadžić

et al. 2005

Journal of Experimental Biology

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These data suggest that nitric oxide (NO) produced by iNOS could also contribute to overall NO-associated regulation of thermogenesis in IBAT. Namely, that iNOS, i.e. NO, in correlation with enhanced thermogenesis, additionally induced IBAT hyperplasia and UCP1 level compared to that induced by low temperature. Cooperative action of decreased apoptosis accompanied by increased tissue hyperplasia and UCP1 level, observed in IBAT of cold-acclimated rats, would be a way of meeting the metabolic requirements for increased thermogenesis.

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Section: Discussionmentioning

confidence: 99%

The effects of l-arginine and l-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue

Petrović

Korać

Buzadžić

et al. 2005

Journal of Experimental Biology

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“…Thrombin also has an important role in shearinduced platelet activation and arterial thrombosis [14,[18][19][20][21]. Furthermore, the involvement of erythrocytes and leucocytes in arterial thrombus formation has been documented [22][23][24]. Thus, increasing evidence supports the concept that in vitro measurement of shear-induced platelet responses using non-anticoagulated blood may provide information that is pathophysiologically relevant to arterial thrombosis in vivo.…”

Section: Discussionmentioning

confidence: 99%

Effects of Clopidogrel on Platelet Activation and Coagulation of Non-Anticoagulated Rat Blood under High Shear Stress

Taka

Okano

Seki

et al. 1999

Pathophysiol Haemos Thromb

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Clopidogrel is a new thienopyridine derivative similar to ticlopidine, which inhibits adenosine diphosphate-induced platelet aggregation. The in vitro effects of clopidogrel on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. Clopidogrel significantly inhibited shear-induced platelet activation and coagulation 2 h after administration at doses of 7.5 and 15 mg/kg. Both ticlopidine (200 mg/kg) and aspirin (200 mg/kg) inhibited shear-induced platelet activation, but not coagulation. The peak inhibition of plaetelet activation by clopidogrel occurred 2 h after oral administration, but significant inhibition persisted even after 24 h. These results suggest that clopidogrel could be a more potent antithrombotic agent than ticlopidine or aspirin, and also that ADP plays an important role in shear-induced platelet activation.

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“…6 Superoxide anion inhibits the action of NO and this inhibition is attenuated by the concomitant application of superoxide dismutase (SOD). 7,8 The endothelium also releases vasoconstrictor factors. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide generated by endothelial cells that counterbalances the vasodilating effect of NO.…”

Section: Me Et Th Ho Od Ds S:mentioning

confidence: 99%

Sevoflurane reduces endothelium-dependent vasorelaxation: role of Superoxide anion and endothelin

et al. 2002

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Aspirin-Stimulated Nitric Oxide Production by Neutrophils After Acute Myocardial Ischemia in Rabbits

Abstract: Our results show that myocardial ischemia/reperfusion stimulates production of NO by circulating neutrophils, an effect that was enhanced in the presence of aspirin. These results suggest a novel interpretation of the protective effect of aspirin on myocardial ischemia damage.

Cited by 45 publications

References 28 publications

The effects of l-arginine and l-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue

The effects of l-arginine and l-NAME supplementation on redox-regulation and thermogenesis in interscapular brown adipose tissue

Effects of Clopidogrel on Platelet Activation and Coagulation of Non-Anticoagulated Rat Blood under High Shear Stress

Sevoflurane reduces endothelium-dependent vasorelaxation: role of Superoxide anion and endothelin

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