“…One area where aspirin is not really used is in the prophylaxis of patients with a high risk of VTE due to prior history and therefore higher baseline risk, with surgeons shying away and preferring low molecular weight heparin in these situations. This paper from Philadelphia (Pennsylvania, USA) adds a lot to what is currently known by asking the question, ‘Could aspirin be used as prophylaxis in the majority of patients with a history of VTE?’ 7 The authors used their own single-institution registry to assemble a cohort study of 36,333 patients, all of whom underwent total joint replacements between 2008 and 2020. Of the whole cohort, 1,087 patients (3.0%) had a history of VTE.…”