Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-α stimulated human umbilical vein endothelial cells

Yang, Yi Yuan; Hu, Chaur Jong; Chang, Su Mei; Tai, Tzu Yi; Leu, Sy Jye

doi:10.1016/j.atherosclerosis.2004.01.024

Cited by 60 publications

(40 citation statements)

References 40 publications

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“…After 24 h, medium with or without aspirin was added and incubated with cells for up to 60 h. The viability of cells after drug treatment was evaluated by MTT assay (Yang et al 2004). MTT (Sigma) (500 lg/ml) was added to each well, and plates were incubated for 4 h at 37°C.…”

Section: Mtt Assaymentioning

confidence: 99%

Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays

et al. 2006

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Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) inhibit proliferation of human colon cancer cells in vitro. Transmission electron microscope detected morphological features of apoptosis in the aspirin-treated (5 mM, 72 h) HT-29 cells in which cyclooxygenoase-2 is catalytically inactive. We investigated aspirin-induced genome-wide expression changes in HT-29 cells and further studied the time- and concentration-dependent expression changes in 374 apoptosis-related genes, which is the first to show stimulation of genome-wide expression of HT-29 cells by aspirin. The most marked effects of aspirin are on ribosome assembly and rRNA metabolism, which could explain why the quasi-apoptotic morphological changes are not accompanied by a classical DNA ladder. These findings demonstrate that aspirin induces apoptosis in HT-29 cells, bolstering the hypothesis that apoptosis may be a mechanism by which NSAIDs inhibit colon carcinogenesis.

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Section: Mtt Assaymentioning

confidence: 99%

Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays

et al. 2006

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“…The high level of TNF-α being released by blood cells can last more J Neurophysiol Neurol Disord 2014 | Vol 1: 203 than 90 days after stroke; however, this level of TNF-α does not have enough intensity to stimulate IL-8, presumably because it is inhibited by the anti platelet drugs given to patients during the therapy period [30][31][32]. At the same time, the expression of IL-8 was also inhibited by anti platelet drugs [32,33]. In addition, the transcription and expression of IL-8 were regulated by some signaling pathways, such as NF-κB, JNK, P38 MAPK and ERK.…”

Section: Discussionmentioning

confidence: 87%

Untitled

2016

Journal of Neurophysiology and Neurological Disorders

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“…[48][49][50] Aspirin, as already mentioned, is also known to possess antiinflammatory properties, and there are several reports showing a reduction in circulating markers caused by treatment with aspirin. 39,50 It might therefore be suggested that the main reason for the beneficial changes in the levels of the inflammatory markers in this study is the anti-inflammatory properties of statins and aspirin. Since 32% and 25% of the population already at baseline were on medication with aspirin and statins, respectively, this may partly explain the highly significant beneficial changes observed.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of 1-year optimal medical treatment with and without additional PTA on inflammatory markers of atherosclerosis in patients with PAD. Results from the Oslo Balloon Angioplasty versus Conservative Treatment (OBACT) study

Nylænde¹,

Kroese

Morken³

et al. 2007

Vasc Med

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Abstract:The influence of optimal medical treatment (OMT) with or without additional percutaneous transluminal angioplasty (PTA) on vascular inflammation in peripheral arterial occlusive disease (PAD) patients was investigated. Patients with intermittent claudication (IC) and angiographically verified PAD were randomized to OMT (n ϭ 28) or OMT ϩ PTA (n ϭ 28) and followed for 12 months. Ankle-brachial index (ABI), treadmill walking distances (WD), visual analogue scale (VAS), and blood sampling for the determination of selected soluble biomarkers were undertaken at baseline and after 3 and 12 months. After both 3 and 12 months, ABI, WD and VAS were highly significantly improved in favour of OMT ϩ PTA (p Ͻ 0.05 for all). Significant improvements were recorded in both groups in serum lipids (p Ͻ 0.01 for all), except for triglycerides, and in the inflammatory markers P-selectin, interleukin-6, interleukin-10, monocyte chemoattractant protein-1 and fibrinogen (p Ͻ 0.05 for all). There were, however, no differences in the changes from baseline between the groups in any variable. Intervention with OMT alone or in combination with PTA did not differ with regard to the effects on serum lipids and markers of inflammation in our population of PAD patients. The combined treatment was, however, better for the treadmill walking distance.

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Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-α stimulated human umbilical vein endothelial cells

Cited by 60 publications

References 40 publications

Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays

Cyclooxygenase-independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays

Untitled

Beneficial effects of 1-year optimal medical treatment with and without additional PTA on inflammatory markers of atherosclerosis in patients with PAD. Results from the Oslo Balloon Angioplasty versus Conservative Treatment (OBACT) study

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