Aspirin inhibits arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in hamster isolated lungs

Relative conversion of arachidonic acid through lipoxygenase and cyclooxygenase pathways by homogenates of diseased periodontal tissues

“…The reaction was stopped by the addition of acetone. After centrifugation, the acetone was evaporated and the remaining aqueous phase was extracted with diethyl ether at pH 7.4, then at pH 3.5 to obtain the lipoxygenase and cyclooxygenase metabolites, respectively (Uotila et al 1981, Paajanen et al 1982).…”

Stability and binding effects of silver(I) complexes at lipoxygenase-1

“…These two mechanisms help to suppress both the formation of malignant tumor and the malignant transformation 5 . Aspirin (aspH, Figure 1) is a well-known NSAID that differs from the rest homologs drugs in the mechanism of its action 6,7 . Among NSAID's, only aspirin inhibits with an irreversible manner and affects more the COX-1 variant than the COX-2 of the enzyme 5,8 .…”

Mechanisms of formation and function of eosinophil lipid bodies: inducible intracellular sites involved in arachidonic acid metabolism

“…It has been well documented that aspirin is devoid of any direct inhibitory effects upon lipoxygenases in leukocytes and platelets (Cerletti et al 1983, Punnonen & Uotila 1984, Cerletti 1985. However, aspirin and aspirin-like drugs were shown to indirectly regulate lipoxygenase activity in different systems (Siegel et al 1980, Paajanen et al 1982, Villanueva et al 1993. In our studies, aspirin significantly inhibited cis-fatty acid-induced priming for enhanced LTB 4 production by neutrophils and LTC 4 production by eosinophils.…”